Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT)

This study has been completed.
University of Pennsylvania
University of Pittsburgh
Forest Laboratories
The John A. Hartford Foundation
Information provided by:
Weill Medical College of Cornell University Identifier:
First received: January 17, 2006
Last updated: NA
Last verified: January 2006
History: No changes posted

The purpose of this study was to determine the effect of a primary care intervention on reducing suicidal ideation and depression in older patients.

Condition Intervention Phase
Suicide, Attempted
Behavioral: treatment guidelines and depression care management
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Prevention of Suicide in Primary Care Elderly: Collaborative Trial

Resource links provided by NLM:

Further study details as provided by Weill Medical College of Cornell University:

Primary Outcome Measures:
  • Hamilton Depression Rating Scale
  • Scale for Suicide Ideation

Secondary Outcome Measures:
  • All cause and cause-specific mortality
  • disability (Sf12; instrumental activities of daily living)

Estimated Enrollment: 1200
Study Start Date: May 1999
Estimated Study Completion Date: August 2003
Detailed Description:

Suicide rates are highest in late life; the majority of older adults who die by suicide have seen a primary care physician in preceding months. Depression is the strongest risk factor for late-life suicide and for suicide’s precursor, suicidal ideation.

The aim of the study was to determine the extent to which an intervention taht combined treatment guidelines with care management reduced rates of depression and suicide ideation in older primary care patients. The study randomized 20 primary care practices from New York City, Philadelphia, and Pittsburgh regions into intervention or usual car. The used a two-stage sampling design that resulted in a representative sample with an oversample of depressed patients (total n=1238 subjects including 598 with a depression diagnosis and 640 with no depression diagnosis). Patients were assessed at baseline, 4, 8, 12, 18 and 24 months.


Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

upcoming appointment with primary care clinician

Exclusion Criteria:

  • inability to give consent
  • minimental status examination <18
  • ability to communicate in English
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00279682

United States, New York
Weill Medical College of Cornell University
White Plains, New York, United States, 10506
United States, Pennsylvania
Universilty of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
Weill Medical College of Cornell University
University of Pennsylvania
University of Pittsburgh
Forest Laboratories
The John A. Hartford Foundation
Principal Investigator: George S Alexopoulos, MD Weill Medical College of Cornell University
Principal Investigator: Ira Katz, MD. Ph.D. University of Pennsylvania
Principal Investigator: Charles F Reynolds, MD University of Pittsburgh
  More Information

Additional publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00279682     History of Changes
Other Study ID Numbers: R01MH59366, R01MH59380, R01MH59381
Study First Received: January 17, 2006
Last Updated: January 17, 2006
Health Authority: United States: Food and Drug Administration

Keywords provided by Weill Medical College of Cornell University:
primary care

Additional relevant MeSH terms:
Depressive Disorder
Suicide, Attempted
Behavioral Symptoms
Mental Disorders
Mood Disorders
Self-Injurious Behavior processed this record on February 26, 2015