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Ultrasound to Detect Evidence for Retinal Detachment in Retinopathy of Prematurity

This study has suspended participant recruitment.
(Studies are suspended until a new ultrasound scanner is acquired.)
Columbia University
Information provided by:
Weill Medical College of Cornell University Identifier:
First received: January 17, 2006
Last updated: May 7, 2008
Last verified: May 2008
Premature infants stand a risk of danger to the layer of the eye that creates sight that, if untreated, can cause severe vision problems, leading to blindness in some cases. This research study will use ultrasound to examine the eye for retinal changes of prematurity.

Condition Intervention
Retinopathy of Prematurity Procedure: Ultrasound examination

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Ultrasound to Detect Evidence for Retinal Detachment in Retinopathy of Prematurity

Resource links provided by NLM:

Further study details as provided by Weill Medical College of Cornell University:

Estimated Enrollment: 30
Study Start Date: December 2004
Estimated Study Completion Date: July 2008
Intervention Details:
    Procedure: Ultrasound examination
    contact ultrasound examination
    Other Name: Quantel Cinescan
Detailed Description:

Retinopathy of prematurity requires the early detection of retinopathy in neonates with a gestational age of < 28 weeks and a birth weight <1500 g. These evaluations require pupillary dilation, diagnostic expertise, consume much time and expense and are not without morbidity.

B-scan ultrasonography using a hand-held probe is part of the current ophthalmologist's armamentarium, providing a non-invasive view of the eye and avoiding the morbidity associated with mydriatic drops used for pupillary dilation.

We will use a simple water bath enclosure for a standard 20 MHz probe currently in general ophthalmic use to determine whether this simple technique might supplant indirect ophthalmoscopy as a screening technique. We will compare, using masked observers, the clinical findings of indirect ophthalmoscopy of neonatal infants with ultrasonic findings to determine if a correlation in the stages of retinopathy of prematurity (ROP) between the two techniques existed.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Premature babies with Retinopathy of Prematurity

Inclusion Criteria:

premature birth

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00279669

United States, New York
Columbia Presbyterian Medical Center
New York, New York, United States, 10032
Sponsors and Collaborators
Weill Medical College of Cornell University
Columbia University
Principal Investigator: Dan H Kauffmann-Jokl, MD Columbia University
Principal Investigator: Ronald H Silverman, PhD Weill Medical College of Cornell University
  More Information

Responsible Party: Dan H. Kauffmann-Jokl, MD, Columbia Presbyterian Medical Center Identifier: NCT00279669     History of Changes
Other Study ID Numbers: ROP
Study First Received: January 17, 2006
Last Updated: May 7, 2008

Keywords provided by Weill Medical College of Cornell University:
Retinopathy of Prematurity

Additional relevant MeSH terms:
Retinal Diseases
Premature Birth
Retinal Detachment
Retinopathy of Prematurity
Eye Diseases
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications
Infant, Premature, Diseases
Infant, Newborn, Diseases processed this record on August 16, 2017