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Role of Epicardial Adipose Tissue in Coronary Artery Disease

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ClinicalTrials.gov Identifier: NCT00279227
Recruitment Status : Unknown
Verified January 2006 by McMaster University.
Recruitment status was:  Recruiting
First Posted : January 19, 2006
Last Update Posted : August 15, 2006
Sponsor:
Collaborator:
Heart and Stroke Foundation of Canada
Information provided by:
McMaster University

Brief Summary:
We sight to evaluate whether patients with coronary artery disease (CAD) have more epicardial fat than patients without CAD, which would suggest that epicardial fat may be more than an “innocent bystander” and be actively involved in the disease process. Its role as a modulator of vascular response and myocardial function could potentially lead to new areas of cardiac research. We also sight to evaluate whether epicardial fat from patients with CAD releases more adipokines than subcutaneous fat from these patients which could prompt studies into the differential regulation of adipokine secretion in this tissue. Thus for e.g., the use of thiazolidinediones (glitazones), statins, ARBs or other compounds that can specifically modulate adipokine secretion could be explored to determine their benefit in ameliorating the effects attributable to increased epicardial fat.

Condition or disease
Coronary Artery Disease Obesity

Study Type : Observational
Enrollment : 50 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Role of Epicardial Adipose Tissue in Coronary Artery Disease
Study Start Date : January 2006
Study Completion Date : December 2006

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All patients elegible for elective cardiac surgery are elegible
  • Ability to provide written informed consent in accordance with GCP guidelines and local legislations.
  • > 18 years of age

Exclusion Criteria:

  • Control patients will not have clinical signs of CAD and will show normal coronary arteries on angiography.
  • Any medical, social or geographic condition, which, in the opinion of the investigator would not allow safe or reliable completion of the protocol.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00279227


Contacts
Contact: Suzana Damjanovic, MLT, CCRA 905-527-4322 ext 44710 suzana@cardio.on.ca

Locations
Canada, Ontario
Hamilton Health Sciences - Cardiovascular Obesity Research and Management Center Recruiting
Hamilton, Ontario, Canada, L8L 2X2
Sub-Investigator: Gianluca Iacobellis, MD PhD         
Principal Investigator: Arya M Sharma, MD FRCPC         
Sponsors and Collaborators
Hamilton Health Sciences Corporation
Heart and Stroke Foundation of Canada
Investigators
Principal Investigator: Arya M Sharma, MD, FRCPC McMaster University

ClinicalTrials.gov Identifier: NCT00279227     History of Changes
Other Study ID Numbers: EPICARD Study
First Posted: January 19, 2006    Key Record Dates
Last Update Posted: August 15, 2006
Last Verified: January 2006

Keywords provided by McMaster University:
coronary artery disease
epicardial adipose tissue
epicardial fat
obesity

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases