Quality of Life in Children Cured of Retinoblastoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2015 by Hadassah Medical Organization
Israel Cancer Association
Information provided by (Responsible Party):
Michael Weintraub, Hadassah Medical Organization
ClinicalTrials.gov Identifier:
First received: January 17, 2006
Last updated: March 17, 2015
Last verified: March 2015
The aim of the study is to assess the quality of life of children who have been cured of retinoblastoma - a malignant eye tumor. The study is questionnaire-based, and uses standardized quality of life assessment tools.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Quality of Life in Children Cured of Retinoblastoma

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • Change in quality of life [ Time Frame: Baseline and 5 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 35
Study Start Date: March 2006
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Detailed Description:

Retinoblastoma is the most common eye tumor of children. It can present in one eye (unilateral) or in both eyes (bilateral). The bilateral form is always hereditary.

Retinoblastoma is a highly curable tumor. Using a combination of surgery, chemotherapy, radiation and local treatment modalities to the eye, over 98% of patients are cured. This means that most children diagnosed with retinoblastoma will become long-term survivors.

The use of surgery (taking out one eye), chemotherapy, and radiation may be associated with long term side-effects, some of which may have significant impact on the quality of life of the child. In addition, in case where the disease is hereditary, additional psychological issues arise.

The aim of our study is to assess, in a comprehensive and standardized fashion, the long term quality of life in children who were treated for retinoblastoma, and who are currently alive and well.

The assessment will include the use of questionnaires that assess quality of life, as well as participation in age-appropriate activities.

Each child, and his/her parent, will be interviewed and the questionnaires completed. The process will take about one hour for each child. No risk or discomfort to the child is involved.


Ages Eligible for Study:   1 Year to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Long term survivors of childhood retinoblastoma

Inclusion Criteria:

  • Past treatment for retinoblastoma
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00278031

Contact: Michael Weintraub, MD 972-2-6777408 michaelw@hadassah.org.il

Hadassah Medical Organization, Jerusalem, Israel Recruiting
Jerusalem, Israel, 91120
Contact: Arik Tzukert, DMD    00 972 2 6776095    arik@hadassah.org.il   
Contact: Hadas Lemberg, PhD    00 972 2 6777572    lhadas@hadassah.org.il   
Principal Investigator: Michael Weintraub, MD         
Sponsors and Collaborators
Hadassah Medical Organization
Israel Cancer Association
Principal Investigator: Michael Weintraub, MD Hadassah Medical Organization
  More Information

Responsible Party: Michael Weintraub, DIrector, Pediatric Hematology Oncology, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00278031     History of Changes
Other Study ID Numbers: qolrb-HMO-CTIL 
Study First Received: January 17, 2006
Last Updated: March 17, 2015
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:
Quality of life

Additional relevant MeSH terms:
Eye Diseases
Eye Neoplasms
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Retinal Diseases
Retinal Neoplasms

ClinicalTrials.gov processed this record on May 26, 2016