This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Mild Valvar Pulmonary Stenosis

This study has been terminated.
(sufficient data collected for significant study results)
Information provided by:
Children's Healthcare of Atlanta Identifier:
First received: January 13, 2006
Last updated: July 5, 2011
Last verified: November 2007
Mild valvar pulmonary stenosis can be detected in 1/10,000 live births. Historical data suggested that most of these patients do well. Nonetheless, the majority of these patients is followed periodically by a pediatric cardiologist and may undergo repeated echocardiographic studies to follow the gradient. Such follow-up can be costly and it is not know if there is any benefit to periodic evaluation.

Congenital Disorders

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Clinical Management of Children With Mild Valvar Pulmonary Stenosis

Resource links provided by NLM:

Further study details as provided by Children's Healthcare of Atlanta:

Enrollment: 146
Study Start Date: January 1984
Study Completion Date: December 2007
Detailed Description:

Young children (less than or equal to 2 years of age) with mild valvar pulmonary stenosis are unlikely to develop worsening stenosis with age and periodic cardiac evaluation is not warranted.

To describe the clinical course of children with mild valvar pulmonary stenosis diagnosed in early childhood. To examine the clinical practice patterns of cardiologists caring for these patients.

Retrospective chart review of all children diagnosed with mild valvar pulmonary stenosis born between 1984 and 2003 and followed by Sibley Heart Center Cardiology. Patient variables will include: pulmonary valve gradient, need for catheterization, exercise intolerance and endocarditis. Practice variables will include: frequency of follow-up, number of echocardiographic studies, exercise limitations.


Ages Eligible for Study:   up to 2 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Children at Children's Healthecare of Atlanta between the dates of 1984 and 2003 with mild valvar pulmonary stenosis that were less than 2 years old

Inclusion Criteria:

  • Children's Healthcare of Atlanta medical charts 1984 to 2003 diagnosed with mild valvar pulmonary stenosis Patients less than or equal to two years of age

Exclusion Criteria:

  • Those who do no meet inclusion criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00277927

United States, Georgia
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Children's Healthcare of Atlanta
Principal Investigator: William T. Mahle, MD Children's Healthcare of Atlanta, Sibley Heart Center Cardiology
  More Information

Responsible Party: William T Mahle, MD, Children's healthcare of Atlanta Identifier: NCT00277927     History of Changes
Other Study ID Numbers: 04-035
Study First Received: January 13, 2006
Last Updated: July 5, 2011

Keywords provided by Children's Healthcare of Atlanta:
Valvar Pulmonary Stenosis

Additional relevant MeSH terms:
Constriction, Pathologic
Pulmonary Valve Stenosis
Pathological Conditions, Anatomical
Heart Valve Diseases
Heart Diseases
Cardiovascular Diseases
Ventricular Outflow Obstruction processed this record on September 21, 2017