Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of Langerhans cell histiocytosis, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may be an effective treatment for Langerhans cell histiocytosis.
PURPOSE: This randomized clinical trial is studying combination chemotherapy to see how well it works in treating young patients with Langerhans cell histiocytosis.
|Childhood Langerhans Cell Histiocytosis||Drug: leucovorin calcium Drug: methotrexate Drug: prednisolone Drug: vinblastine sulfate|
|Study Design:||Allocation: Randomized
Primary Purpose: Treatment
|Official Title:||Treatment Protocol of the Third International Study For Langerhans Cell Histiocytosis|
|Study Start Date:||April 2001|
|Study Completion Date:||June 2013|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00276757
Show 33 Study Locations
|Study Chair:||Kenneth L. McClain, MD, PhD||Texas Children's Cancer Center|