Activation and Recruitment of GIL During Hp Infection
Recruitment status was: Recruiting
|Study Design:||Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
|Official Title:||Activation and Recruitment of Gastric Infiltrating Lymphocytes During H. Pylori Infection|
|Study Start Date:||January 2006|
|Estimated Study Completion Date:||December 2008|
Specific Aim #1: Characterization of the gastric infiltrating T cells from H. pylori gastritis patients A. Patients H. pylori infected gastritis and asymptomatic patients are selected from National Taiwan University hospital. The gastric biopsy specimen are taken from endoscopic biopsy in routine health check up or panendoscopic examination for the despeptic patients. HP negative gastritis patients will also be studied for negative control.
B. Immunohistochemical identification of T cells and expression of chemokine receptors.
Specific Aim #2 . Isolation and characterization of chemokines and chemokine receptors of the infiltrating lymphocytes in H. pylori-associated gastritis tissue
A. Isolation of gastric infiltrating lymphocyte B. Identification of the expression of chemokine receptor in gastric infiltrating lymphocytes by flow cytometry C. Detection of expression of chemokines in gastric tissues
Please refer to this study by its ClinicalTrials.gov identifier: NCT00275886
|National Taiwan University Hospital|
|Principal Investigator:||Ping-Ning Hsu, MD, PhD||Department of Immunology|