Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
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|ClinicalTrials.gov Identifier: NCT00275730|
Recruitment Status : Completed
First Posted : January 12, 2006
Last Update Posted : February 12, 2007
Prostaglandins (PG) are known to alter regional ocular blood flow and exhibit vasoactive properties in isolated ocular blood vessels. A variety of animal experiments indicate that endogenous PGs play a role in the regulation of retinal (RBF) and choroidal (ChBF) blood flow. There is also evidence that the prostaglandin pathway is involved in the activation of NO production in humans, however, the mechanisms for interactions between PG and NO in ocular vasculature are still unclear.
Animal studies suggest that retinal and choroidal blood flow decrease after administration of indomethacin (a nonspecific cyclooxygenase inhibitor). More recently, it has been shown that indomethacin injected intravenously decreased optic nerve oxygen tension and reduced the CO2 reactivity. This is probably the result of decreased blood flow through vasoconstriction of vessels in the optic nerve. Systemic administration of indomethacin also diminishes cerebral, renal and mesenteric blood flow by an unknown mechanism. However, no clinical trials exist so far investigating the effects of indomethacin on ocular blood flow. Therefore, the aim of this study is to investigate the effect of indomethacin on ocular blood flow in healthy humans.
|Condition or disease||Intervention/treatment||Phase|
|Ocular Physiology Regional Blood Flow||Drug: indometacine (drug) effect on ocular blood flow||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||12 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers|
|Study Start Date :||January 2006|
|Study Completion Date :||August 2006|
- Retinal and choroidal blood flow
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00275730
|Department of Clinical Pharmacology|
|Vienna, Austria, 1090|
|Principal Investigator:||Gabriele Fuchsjaeger-Mayrl, MD||Department of Clinical Pharmacology, Medical University of Vienna|