Cosopt Versus Xalatan

This study has been completed.
Information provided by:
Pharmaceutical Research Network Identifier:
First received: January 6, 2006
Last updated: January 8, 2007
Last verified: January 2007
To compare the 24-hour efficacy and safety, measured every three hours, of the dorzolamide/timolol fixed combination given twice daily versus latanoprost and placebo each given once daily.

Condition Intervention Phase
Open-Angle Glaucoma
Ocular Hypertension
Drug: timolol maleate 0.5%
Drug: dorzolamide/timolol maleate fixed combination
Drug: latanoprost 0.005%
Drug: placebo
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Pharmaceutical Research Network:

Study Start Date: April 2005
Estimated Study Completion Date: December 2005

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • adults with primary open-angle, pigmentary, or exfoliation glaucoma, or ocular hypertenstion
  • intraocular pressure should be 22 to 30 mm Hg inclusive on timolol BID at the 08:00 H
  • ETDRS visual acuity must be 1.0 or better in both eyes

Exclusion Criteria:

  • any contraindications to study medications
  • any anticipated change in systemic hypertensive therapy during the trial
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00273429

United States, Florida
Central Florida Eye Associates
Lakeland, Florida, United States, 33805
United States, Illinois
Midwest Eye Center SC
Bourbonnais, Illinois, United States, 60914
Sponsors and Collaborators
Pharmaceutical Research Network
Study Director: William C. Stewart, MD Pharmaceutical Research Network, LLC
Principal Investigator: Jay Mulaney, MD Central Florida Eye Associates
Principal Investigator: Sriram Sonty, MD, FACS Midwest Eye Center SC
  More Information Identifier: NCT00273429     History of Changes
Other Study ID Numbers: PRN 04-015 
Study First Received: January 6, 2006
Last Updated: January 8, 2007
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases
Maleic acid
Adrenergic Agents
Adrenergic Antagonists
Adrenergic beta-Antagonists
Anti-Arrhythmia Agents
Antihypertensive Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Physiological Effects of Drugs processed this record on May 26, 2016