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Clinical and Genetic Studies in Families With Myopia and Related Diseases

This study has been completed.
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Eye Institute (NEI) ) Identifier:
First received: January 5, 2006
Last updated: June 30, 2017
Last verified: July 29, 2016

This study will examine the inheritance of myopia in families of various nationalities and ethnic backgrounds to identify gene changes that cause myopia or similar diseases and to better understand these conditions. In patients with myopia, the eye does not focus light accurately on the retina (tissue that lines the back of the eye), so that objects at a distance appear blurry. Myopia may occur alone, with other vision problems such as retinal dislocations, cataract or glaucoma, or with other problems such as joint or skin problems.

People with myopia (usually those from families with several affected members) and control subjects with normal vision may be eligible for this study.

Each participant undergoes the following procedures:

  • Blood draw for genetic testing related to the disorders under study
  • Medical and family history, including drawing a family tree to explore vision problems in the family
  • Complete eye examination, including refraction (pupil dilation) and visual acuity testing, photographs of the retina and possibly lens, and specialized tests to measure field of vision, color vision and ability to see in the dark


Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Retrospective
Official Title: Clinical and Molecular Studies in Families With Myopia and Related Diseases

Further study details as provided by National Institutes of Health Clinical Center (CC) ( National Eye Institute (NEI) ):

Primary Outcome Measures:
  • Statistically significant linkage

Enrollment: 9
Study Start Date: December 21, 2005
Estimated Study Completion Date: July 29, 2016
Detailed Description:

Objective: This project, Clinical and Molecular Studies in Families with Myopia and Related Diseases will study the inheritance of myopia in families of many nationalities and ethnic backgrounds in order to identify the genes that, when mutated, cause myopia, high myopia, or similar diseases and the pathophysiology through which they act.

Study Population: The number of subjects to be enrolled has no logical upper limit, but will be at least 250 and not more than 2000 during the next 5 years. The study consists of ascertaining individuals and especially families with multiple individuals, affected by myopia or related ocular diseases.

Design: These patients and their families will undergo detailed ophthalmological examinations and, where indicated, additional non-investigational examinations to characterize disease in their families and determine their affectation status. A blood sample will be collected from each individual for isolation of DNA and in some individual s biochemical studies or for lymphoblastoid transformation to establish a renewable source of DNA. Linkage analysis, physical mapping, and mutational screening will be carried out to identify the specific the gene and the mutations in it that are associated with myopia in this family. If necessary, the gene product or blood sample will be characterized biochemically. The study will enroll subjects at the NEI and at collaborating centers including the Zhongshan Ophthalmic Center of Sun Yat-Sen University, Guangzhou, China.

Outcome Measures: Linkage will be determined using the lod score method and mutations in specific genes will be assessed using a combination of residue conservation, blosum score, and molecular modeling. Biochemical, metabolic, and physiological effects will be individualized to the specific assay.


Ages Eligible for Study:   4 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

    1. Individuals or family members of individuals with myopia, either congenital, childhood, or older.
    2. Adults must be capable of providing their own consent.
    3. All subjects must be able to cooperate with study examination and phlebotomy.
    4. Older than 4 years of age.


  1. Diseases, infections, or trauma that mimic primary myopia.
  2. Children requiring sedation for study procedures.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00272376

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzho, China
Sponsors and Collaborators
National Eye Institute (NEI)
Principal Investigator: James F Hejtmancik, M.D. National Eye Institute (NEI)
  More Information

Responsible Party: National Eye Institute (NEI) Identifier: NCT00272376     History of Changes
Other Study ID Numbers: 060058
Study First Received: January 5, 2006
Last Updated: June 30, 2017

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Eye Institute (NEI) ):

Additional relevant MeSH terms:
Refractive Errors
Eye Diseases processed this record on September 21, 2017