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Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents

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ClinicalTrials.gov Identifier: NCT00272233
Recruitment Status : Completed
First Posted : January 4, 2006
Last Update Posted : March 20, 2007
Sponsor:
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Research Resources (NCRR)
Information provided by:
Yale University

Brief Summary:
Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function. The purpose of this study is to determine the effects of sleep loss on blood hormone levels and blood vessel function in medical trainees.

Condition or disease
Sleep Deprivation

Detailed Description:

Context: Sleep loss is associated with increased blood levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Medical residents are often deprived of normal sleep during extended work shifts, but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown.

Objective: We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction.

Design: Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind, randomized crossover design.

Setting: University hospital medical intensive care unit

Patients or Other Participants: Twenty-two healthy medical residents were studied during a medical intensive care unit rotation.

Main Outcome Measure(s): Sleep related cytokines (interleukin-6 and tumor necrosis factor), serum markers of vascular inflammation (C-reactive protein), and flow-mediated dilation in the brachial artery.


Study Type : Observational
Enrollment : 22 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Study Start Date : December 2004
Study Completion Date : June 2005




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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Medical resident in MICU rotation
  • Non-smoker
  • Body mass index <28 kg/m2

Exclusion Criteria:

  • Systolic blood pressure >140 mmHg; Diastolic blood pressure >90 mmHg
  • Known history of diabetes mellitus, hypertension, hyperlipidemia
  • Known history of acute or chronic inflammatory or infectious disease
  • Known history of sleep disturbance unrelated to work
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00272233


Locations
United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06510
Sponsors and Collaborators
Yale University
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Research Resources (NCRR)
Investigators
Principal Investigator: Stuart D Katz, MD Yale University

ClinicalTrials.gov Identifier: NCT00272233     History of Changes
Other Study ID Numbers: HIC26414
NIH NHLBI K24 04024
First Posted: January 4, 2006    Key Record Dates
Last Update Posted: March 20, 2007
Last Verified: January 2006

Keywords provided by Yale University:
Inflammation Mediators [D23.469]
Cardiovascular Physiologic Phenomena [G09.330.553]

Additional relevant MeSH terms:
Sleep Deprivation
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders