Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
|Study Design:||Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:||Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents|
|Study Start Date:||December 2004|
|Estimated Study Completion Date:||June 2005|
Context: Sleep loss is associated with increased blood levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Medical residents are often deprived of normal sleep during extended work shifts, but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown.
Objective: We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction.
Design: Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind, randomized crossover design.
Setting: University hospital medical intensive care unit
Patients or Other Participants: Twenty-two healthy medical residents were studied during a medical intensive care unit rotation.
Main Outcome Measure(s): Sleep related cytokines (interleukin-6 and tumor necrosis factor), serum markers of vascular inflammation (C-reactive protein), and flow-mediated dilation in the brachial artery.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00272233
|United States, Connecticut|
|Yale University School of Medicine|
|New Haven, Connecticut, United States, 06510|
|Principal Investigator:||Stuart D Katz, MD||Yale University|