Benazepril for Advanced Chronic Renal Insufficiency

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00270426
Recruitment Status : Terminated
First Posted : December 26, 2005
Last Update Posted : May 5, 2006
Information provided by:
Southern Medical University, China

Brief Summary:
The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.

Condition or disease Intervention/treatment Phase
Chronic Kidney Failure Drug: Benazepril Not Applicable

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment

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U.S. FDA Resources

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. serum creatinine concentration 1.5-5.0 mg/dL (133-442 µmol/L)
  2. creatinine clearance 20 to70 mL/min/1.73 m2, with variations of less than 30 percent in the three months before the screening evaluation
  3. non-diabetic renal disease
  4. persistent proteinuria (defined as urinary protein excretion greater than 0.3 g/day for three or more months without evidence of urinary-tract infection or overt heart failure [New York Heart Association class III–IV]).

Exclusion Criteria:

  • immediate need for dialysis; treatment with corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular accident in the year preceding the trial; connective-tissue disease; obstructive uropathy.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00270426

Sponsors and Collaborators
Southern Medical University, China
Principal Investigator: Fan Fan Hou, M.D.,Ph.D. Southern Medical University

Publications of Results: Identifier: NCT00270426     History of Changes
Other Study ID Numbers: SouthernMUC
First Posted: December 26, 2005    Key Record Dates
Last Update Posted: May 5, 2006
Last Verified: March 1999

Keywords provided by Southern Medical University, China:
Advanced Chronic Renal Insufficiency

Additional relevant MeSH terms:
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Angiotensin-Converting Enzyme Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antihypertensive Agents