Outcome of Crisis Intervention for Subjects With Borderline Personality Disorder or Post-Traumatic Stress Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00269139
Recruitment Status : Unknown
Verified December 2005 by Laddis, Andreas, M.D..
Recruitment status was:  Not yet recruiting
First Posted : December 23, 2005
Last Update Posted : February 20, 2006
Information provided by:
Laddis, Andreas, M.D.

Brief Summary:

Dr. Laddis will test a hypothesis about the nature and the management of behavioral crises in patients with borderline personality disorder (BPD) or post-traumatic stress disorder (PTSD). The term "behavioral crisis" is used strictly for periods of uncontrollable urges to repeat mental or outward activity, e.g., flashbacks, cutting, binging on food, drugs or sex, with no intervals to rethink one's priorities or to consider others' direction.

The clinical hypothesis states, in two steps, that:

  1. the perception of a life crisis precedes and then underlies every behavioral crisis;
  2. the behavioral crisis resolves promptly and all symptoms end if the clinicians engage the patient about his management of the life crisis that underlies the symptoms.

Condition or disease Intervention/treatment Phase
Borderline Personality Disorder Post-Traumatic Stress Disorders Behavioral: Crisis resolution Phase 1

Detailed Description:

Subjects in the experimental group will be treated by Dr. Laddis after their admission to a crisis stabilization unit (CSU) or to an inpatient unit (IPU) for a behavioral crisis. Subjects will be included at random, as assigned to Dr. Laddis according to his routine duties at those units.

Subjects in the control group will receive treatment for behavioral crisis according to the preference of the clinical staff at other comparable units. That treatment will constitute "treatment as usual". Clinicians in the control settings will not be informed about the experimental hypothesis, the clinical intervention and the contingent outcomes.

The subjects will be tested for the results of treatment 12-24 hours after composition of a treatment plan. The testing will be done with the Brief Psychiatric Rating Scale (BPRS), as well as with a set of criteria devised by Dr. Laddis to measure the outward behavior and the mental events during behavioral crisis. The patients and the attending frontline staff will be interviewed also about their beliefs in regard to what, among the clinicians' interventions, made a difference for the course of the behavioral crisis, for better or for worse. The raters will be trained for interrater reliability and they will not be informed about the hypothesis.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Study of Outcome With an Intervention From the Cape Cod Model of Psychotherapy for Subjects in a Behavioral Crisis and With the Diagnosis of Borderline Personality Disorder (BPD) or Post-Traumatic Stress Disorder (PTSD)

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Primary Outcome Measures :
  1. Brief Psychiatric Rating Scale (BPRS) scores
  2. Scores on Client Observation and Client Interview, tools designed for this study

Secondary Outcome Measures :
  1. Patient interview and ratings for the value of the clinicians' interventions
  2. Staff interview and ratings for their own interventions

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosed with BPD or PTSD, with a structured interview according to the current diagnostic manual
  • In behavioral crisis

Exclusion Criteria:

  • Brain damage
  • Currently intoxicated with alcohol or drugs or in withdrawal

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00269139

Contact: Andreas Laddis, MD 508-320-7895

United States, Massachusetts
Cape Cod and Islands Community Mental Health Center Not yet recruiting
Pocasset, Massachusetts, United States, 02559
Principal Investigator: Andreas Laddis, MD         
Sponsors and Collaborators
Laddis, Andreas, M.D.
Principal Investigator: Andreas Laddis, MD Cape Cod and Islands Community Mental Health Center

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00269139     History of Changes
Other Study ID Numbers: 719371
First Posted: December 23, 2005    Key Record Dates
Last Update Posted: February 20, 2006
Last Verified: December 2005

Keywords provided by Laddis, Andreas, M.D.:
Behavioral crisis
Perception of social crisis
Repetition compulsion
Intrusive mental events
Uncontrollable urges

Additional relevant MeSH terms:
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Personality Disorders
Borderline Personality Disorder
Pathologic Processes
Trauma and Stressor Related Disorders
Mental Disorders