Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00268112
Recruitment Status : Terminated (sufficient data collected for analysis)
First Posted : December 22, 2005
Last Update Posted : March 16, 2012
Information provided by:
Children's Healthcare of Atlanta

Brief Summary:

Spontaneous resynchronization of dyskinetic segments of the left ventricle occurs after coronary bypass surgery in adults and has been shown in some children. It is, however, unknown what degree of dyskinesis is likely to be reversible in infants with ischemia from anomalous coronary arteries and what criteria would indicate that a resynchronization strategy of biventricular pacing might be needed.

These questions need data from quantitative serial tissue Doppler observations of patients from pre-operative to late post-operative follow-up.

Condition or disease
Congenital Disorders

Detailed Description:

We have previously studied, at Children's Healthcare of Atlanta, Egleston Hospital, 2 patients with ALCAPA and one other patient is currently enrolled in a prospective study after recent surgery, also at Children's Healthcare of Atlanta. We propose to study these 3 patients with this rare defect concurrently with their routine echocardiographic evaluations. Data will then be taken off-line for analysis.

Standard deviations of times to peak contraction velocity will be assessed for twelve cardiac segments. These will be reevaluated at follow up intervals after surgery on previously obtained echocardiograms. Those subjects in whom improvement of cardiac function, Left Ventricular Ejection Fraction (LVEF) and mitral regurgitation is seen will be compared to those in whom no improvement occurs.

Study Type : Observational
Actual Enrollment : 3 participants
Time Perspective: Retrospective
Official Title: Resynchronization of Left Ventricular Contraction After Re-implantation of Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA) Evaluated by Tissue Doppler Imaging
Study Start Date : January 2004
Actual Study Completion Date : December 2006

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   up to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cardiac pediatric patients

Inclusion Criteria:

  • Re-implantation of an anomalous left coronary artery from the pulmonary artery

Exclusion Criteria:

  • those patients who do not meet inclusion criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00268112

United States, Georgia
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Children's Healthcare of Atlanta
Principal Investigator: Derek A. Fyfe, MD, PhD Sibley Heart Center Cardiology at Children's Healthcare of Atlanta Identifier: NCT00268112     History of Changes
Other Study ID Numbers: 05-203
First Posted: December 22, 2005    Key Record Dates
Last Update Posted: March 16, 2012
Last Verified: December 2006

Keywords provided by Children's Healthcare of Atlanta:
Tissue Doppler Imaging

Additional relevant MeSH terms:
Bland White Garland Syndrome
Coronary Vessel Anomalies
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Arterio-Arterial Fistula
Vascular Fistula
Vascular Malformations
Heart Diseases
Vascular Diseases
Congenital Abnormalities
Pathological Conditions, Anatomical