Radiofrequency Ablation of Ectopic Atrial Tachycardia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00267982
Recruitment Status : Terminated (significant conclusive data has been collected)
First Posted : December 22, 2005
Last Update Posted : July 6, 2011
Information provided by:
Children's Healthcare of Atlanta

Brief Summary:

A retrospective chart review will be performed on 50 patients who received RFA for the treatment of EAT between August 1992 and August 2003 at Children's Healthcare of Atlanta.

The use of the CARTO/Biosense catheter has improved outcomes with decreased radiation exposure to patients.

Condition or disease
Congenital Disorders

Detailed Description:

Ectopic Atrial Tachycardia (EAT) is a relatively rare arrhythmia in the pediatric population. It is defined by a run of more than 3 premature atrial contractions together. In EAT, the arrhythmia tends to increase in rate over a period of time and then slows down gradually to a normal rhythm. Ectopic Atrial Tachycardia (EAT) is mostly encountered in patients with structurally normal hearts however, occasionally physicians do observe this type of disorder in children following surgery for congenital heart defects. Current reports suggest that EAT occurs in approximately 1 in 10,000 children (Hamilton, 2002).

Children with EAT usually present with a multitude of symptoms. The most common symptoms associated with pediatric EAT are palpitations, chest pain, lightheadedness, presyncope, and dyspnea. Other symptoms can include exercise intolerance and congestive heart failure. These are usually late manifestations. In the patients with tachycardia induced CM, the time of development of CM is dependent on the rate and duration of the tachycardia however, in most cases, dilation is present upon diagnosis. This CM can be reversed with successful treatment of the arrhythmia.

The treatment for chronic EAT includes medications such as adenosine and for difficult to control cases, Radiofrequency Ablation (RFA). RF ablation has been successful in curing EAT, with success rates ranging from 75-100%. It has been shown that the complication rates are similar to other RF ablation procedures, with a higher risk of recurrence (Hamilton, 2002).

At Children's Healthcare of Atlanta, the cardiac catheterization lab performs approximately 10 Radiofrequency ablations for EAT each year. The goal of this retrospective review is to assess the frequency of recurrence of the EAT among a subset of patients receiving treatment between August 1992 - August 2003

Study Type : Observational
Actual Enrollment : 25 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: A Retrospective Review of Outcomes Related to Radiofrequency Ablation of Ectopic Atrial Tachycardia
Study Start Date : August 1992
Actual Primary Completion Date : August 2003
Actual Study Completion Date : February 2008

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Ages Eligible for Study:   up to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study population is subjects received RFA for treatment of EAT between August 2992 and August 2003 at Children's Healthcare of Atlanta

Inclusion Criteria:

  • 50 patients who received RFA for treatment of EAT between August 2992 and August 2003
  • Treatment at Children's Healthcare of Atlanta

Exclusion Criteria:

  • those who do not meet inclusion criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00267982

United States, Georgia
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Children's Healthcare of Atlanta
Principal Investigator: Patrick A Frias, MD Sibley Heart Center Cardiology of Children's Healthcare of Atlanta

Responsible Party: Patrick Frias, MD, Children's Healthcare of Atlanta Identifier: NCT00267982     History of Changes
Other Study ID Numbers: 03-064
First Posted: December 22, 2005    Key Record Dates
Last Update Posted: July 6, 2011
Last Verified: June 2011

Keywords provided by Children's Healthcare of Atlanta:
Radiofrequency Ablation
Ectopic Atrial Tachycardia

Additional relevant MeSH terms:
Cardiac Complexes, Premature
Tachycardia, Ectopic Atrial
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Tachycardia, Supraventricular