Brain Changes in Adolescents While Imagining and Observing Aggressive Behavior
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|ClinicalTrials.gov Identifier: NCT00267891|
Recruitment Status : Completed
First Posted : December 21, 2005
Last Update Posted : July 2, 2017
This study will use functional magnetic resonance imaging (fMRI) to examine what happens in the brains of adolescents when they are exposed to violent media and how imagining aggressive behavior affects brain function. The study will measure physiological changes (such as the amount of electricity generated by the skin, heart rate, and breathing rate) related to these tasks during fMRI. MRI uses a magnetic field and radio waves to obtain images of body organs and tissues. For fMRI, the subject performs certain tasks during the MRI scanning to examine changes in the brain regions that are involved with those tasks. During the scan, the subject lies in a metal cylinder (the scanner), wearing earplugs to muffle loud noises that occur with the scanning.
Healthy right-handed native English-speaking males between 14 and 17 years of age may be eligible for this study. Candidates are screened with a neurological examination and neuropsychological testing that includes questions about their feelings, experiences, and behavior, and tests of reading level and intelligence.
Participants undergo fMRI and fill out questionnaires before and after the scanning. Some children are asked to play 20 minutes of video games before the test. During the scan, the child views short neutral video clips and video clips of people fighting or imagine self-defense situations. The child is asked to rate the video clips for their aggressive content or tell how he or she feels about the imagined situations. Two small straps are wrapped around the child's index and middle fingers to measure changes in the amount of electricity generated by the skin, and a strap at the ring finger measures the child's heart rate. A band around the child's chest records breathing rates.
Children who cannot or do not want to undergo MRI testing may be asked to view commercially available video clips of people fighting and neutral video scenes, such as sports scenes. They are asked to rate them on their violent content and excitement, or to rate the video games they have played on their violent/nonviolent content and their popularity. In addition, the children fill out questionnaires about their media use and exposure to violence.
All participating families are contacted by telephone 1 day and 2 weeks after the experiment for parents to answer questions about how the child has been doing and for the children to answer questions about their feelings.
|Condition or disease|
Objective. The purpose of the protocol is to localize the prefrontal cortical regions mediating aggressive behavior. Utilizing two different experimental neuropsychological tasks during functional MRI, we will investigate hypotheses regarding the role of the ventro-medial prefrontal cortex in processing imagined and observed aggressive behavior. Additionally, we will determine the relationship between non-frontal neural structures involved in emotional expression, such as the amygdala, and the prefrontal structures involved in executive functions that may modulate aggressive behavior. We will record skin conductance responses (SCRs), heart rates, and respiration during the experiments to investigate autonomic changes during the processing of aggressive behavior.
Study Population. In three separate studies, normal adolescent volunteers will participate in experiments dealing with processing of aggressive behavior using functional magnetic resonance imaging (fMRI). In addition, we will conduct two pre-studies in normal adolescent volunteers in order to determine appropriate stimuli for the fMRI studies.
Design. The experiments we are conducting will employ within-subject, rapid event-related fMRI designs to determine whether the observation and imagination of aggressive behavior deactivates the ventro-medial prefrontal cortex (VM-PFC) and how varying intensities of imagined and observed aggressive acts may influence changes in activation patterns in the VM-PFC.
Outcome Measures. The data collected will consist of fMRI activation images corresponding to varying intensities of observed or imagined aggression, questionnaire results, amplitudes of the skin conductance responses, heart rates, and respiration parameters. The results gained from this protocol will provide further evidence for the role of the ventro-medial prefrontal cortex in processing aggressive behavior, particularly in adolescents.
|Study Type :||Observational|
|Actual Enrollment :||88 participants|
|Official Title:||Changes in Activation Patterns in the Ventro-Medial Prefrontal Cortex of Healthy Adolescents During the Imagination and Observation of Aggressive Behavior|
|Study Start Date :||December 14, 2005|
|Study Completion Date :||August 12, 2010|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00267891
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|