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Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) Patients

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ClinicalTrials.gov Identifier: NCT00267241
Recruitment Status : Completed
First Posted : December 20, 2005
Last Update Posted : April 28, 2015
Sponsor:
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital

Brief Summary:
The aim of this study is to evaluate the effects in terms of gas exchange, respiratory mechanics and comfort of breathing, of different assisted mechanical ventilation in ALI/ARDS patients.

Condition or disease Intervention/treatment Phase
Respiratory Distress Syndrome, Adult Other: Mechanical Ventilation Not Applicable

Detailed Description:
ALI/ARDS patients (during assisted ventilation) will be ventilated with different types of assisted ventilation (pressure support, pressure support plus sigh, BIPAP, variable ventilation) and gas exchange, comfort of breathing, respiratory mechanics and pattern of breathing will be measured.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Effects of Different Assisted Mechanical Ventilation in ALI/ARDS Patients
Study Start Date : December 2005
Actual Primary Completion Date : November 2014
Actual Study Completion Date : November 2014


Arm Intervention/treatment
Experimental: 1
ALI/ARDS patients
Other: Mechanical Ventilation
Four different types of assisted ventilation (pressure support, pressure support plus sigh, BIPAP, variable ventilation)



Primary Outcome Measures :
  1. Gas exchange and respiratory mechanics [ Time Frame: 5 minutes ]


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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with ALI/ARDS

Exclusion Criteria:

  • COPD patients
  • Barotrauma
  • Hemodynamic instability
  • Age less than 18

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00267241


Locations
Italy
Policlinico Hospital
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Investigators
Principal Investigator: Davide Chiumello, MD Policlinico Hospital

Responsible Party: Davide Chiumello, MD, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00267241     History of Changes
Other Study ID Numbers: 1600
First Posted: December 20, 2005    Key Record Dates
Last Update Posted: April 28, 2015
Last Verified: April 2015

Keywords provided by Davide Chiumello, Policlinico Hospital:
ARDS
ALI
respiratory mechanics
gas exchange
assisted ventilation

Additional relevant MeSH terms:
Syndrome
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Disease
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury