We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Brain Aging Project--Kansas University

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00267124
First Posted: December 20, 2005
Last Update Posted: April 6, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
University of Kansas
National Institute on Aging (NIA)
Information provided by (Responsible Party):
University of Kansas Medical Center
  Purpose
The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.

Condition
Alzheimer's Disease

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Prospective
Official Title: KU Brain Aging Project

Resource links provided by NLM:


Further study details as provided by University of Kansas Medical Center:

Biospecimen Retention:   Samples With DNA
Blood samples are collected analyzed and banked as whole blood, serum, white blood cells

Enrollment: 172
Actual Study Start Date: November 2004
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
elderly people who have normal cognition
2
elderly people who have mild to moderate Alzheimer's disease

Detailed Description:

The mission of the KU Brain Aging Project is to promote healthy brain aging. How the brain changes with age is not well-characterized and even less is known about the factors influencing the rate of brain aging. Thus, we are using MRI scans to examine the structure of the brain in relation to important lifestyle factors. This will allow us to better understand the processes influencing the brain as it ages. In turn, this will help identify specific ways to promote healthy brain aging and, perhaps, prevent the onset of Alzheimer's disease.

Participants complete 4 visits over several months. The first visit entails a clinical evaluation and memory testing involving the use of paper and pencil testing. The second visit is an MRI brain scan which lasts approximately one hour. The third visit involves drawing blood for laboratory testing and blood banking for future lab studies, lasting roughly 4 hours. The glucose tolerance test is administered. The fourth and final visit is an assessment of the participant's metabolism and exercise testing. This visit lasts approximately two hours.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
KU memory clinic patients, volunteers from the community, and the states of Kansas and Missouri
Criteria

Inclusion Criteria:

  • Age 65 years or older
  • Healthy male or female
  • Normal control volunteers and early Alzheimer's disease patients
  • Clinical Dementia Rating of 0, 0.5, or 1.0
  • On stable doses of medications

Exclusion Criteria:

  • Unstable angina
  • Schizophrenia
  • Clinical signs of depression; major depression; mental health disorder; nervous system disorder
  • Significant visual/auditory impairment
  • Significant system illness; cancer
  • Pacemaker/metal
  • Thyroid problems
  • Kidney dialysis
  • Organ transplant
  • Alcoholism
  • Heart surgery
  • Insulin
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00267124


Locations
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Sponsors and Collaborators
University of Kansas Medical Center
University of Kansas
National Institute on Aging (NIA)
Investigators
Principal Investigator: Jeffrey Burns, MD University of Kansas Medical Center, Landon Center on Aging
  More Information

Additional Information:
Responsible Party: University of Kansas Medical Center
ClinicalTrials.gov Identifier: NCT00267124     History of Changes
Other Study ID Numbers: IA0089
1R03AG026374-01 ( U.S. NIH Grant/Contract )
First Submitted: December 16, 2005
First Posted: December 20, 2005
Last Update Posted: April 6, 2017
Last Verified: April 2017

Keywords provided by University of Kansas Medical Center:
cognitive decline
dementia
neuroimaging

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders