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Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection

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ClinicalTrials.gov Identifier: NCT00265408
Recruitment Status : Withdrawn
First Posted : December 14, 2005
Last Update Posted : December 8, 2014
Information provided by:

Study Description
Brief Summary:
Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection.

Condition or disease Intervention/treatment Phase
Ischemic Stroke Drug: aspirin Drug: warfarin Phase 1

Detailed Description:
20 patients with cervicocephalic arterial dissection will be randomized to open-label aspirin or warfarin, rate of stroke and adverse events will be endpoints.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection
Study Start Date : December 2005
Estimated Study Completion Date : March 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Thinners
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: aspirin Drug: aspirin
Experimental: warfarin Drug: warfarin

Outcome Measures

Primary Outcome Measures :
  1. Incidence of stroke by one year. [ Time Frame: 1 year ]

Secondary Outcome Measures :
  1. Recurrent dissection by one year. [ Time Frame: 1 year ]
  2. Incidence of TIA by one year. [ Time Frame: 1 year ]
  3. Incidence of major and minor bleeding episodes by one year. [ Time Frame: 1 year ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical and imaging diagnosis of cervicocephalic arterial dissection within 3 months.

Exclusion Criteria:

  • Any contraindication to aspirin or warfarin.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00265408

United States, California
UCSD Medical Center
San Diego, California, United States, 92103
Sponsors and Collaborators
University of California, San Diego
Principal Investigator: Matt B Jensen, MD UCSD Stroke Center
More Information

ClinicalTrials.gov Identifier: NCT00265408     History of Changes
Other Study ID Numbers: UCSD IRB #051253
First Posted: December 14, 2005    Key Record Dates
Last Update Posted: December 8, 2014
Last Verified: March 2007

Keywords provided by University of California, San Diego:
Cervicocephalic Arterial Dissection

Additional relevant MeSH terms:
Aneurysm, Dissecting
Vascular Diseases
Cardiovascular Diseases
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors