We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00265252
First Posted: December 14, 2005
Last Update Posted: October 12, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Merck Sharp & Dohme Corp.
National Cheng-Kung University Hospital
National Taiwan University Hospital
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital
  Purpose
To determine the cumulative incidence of total hip replacement, time to event after treatment with Fosamax or placebo during the study peroid

Condition Intervention Phase
Non-Traumatic Osteonecrosis Drug: Alendronate Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Prevention
Official Title: Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis

Resource links provided by NLM:


Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • the cumulative of total hip replacement

Secondary Outcome Measures:
  • necrotic area
  • Harris hip score

Estimated Enrollment: 60
Study Start Date: June 2005
Estimated Study Completion Date: June 2008
Detailed Description:
To determine the cumulative incidence of total hip replacement and collpase of femoral head, time to event after treatment with Fosamax or placebo during the study peroid
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • osteonecrosis of femoral head
  • be able to provide singed informed consent

Exclusion Criteria:

  • prior bisphosphonate use
  • pregnant or lactating woman
  • bilateral hip replacement
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00265252


Locations
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 807
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Merck Sharp & Dohme Corp.
National Cheng-Kung University Hospital
National Taiwan University Hospital
Investigators
Study Chair: Gwo-Jaw Wang, MD Kaohsiung Medical University
  More Information

Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00265252     History of Changes
Other Study ID Numbers: fosamax 01
First Submitted: December 12, 2005
First Posted: December 14, 2005
Last Update Posted: October 12, 2017
Last Verified: April 2007

Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
osteonecrosis
total hip replacement

Additional relevant MeSH terms:
Osteonecrosis
Bone Diseases
Musculoskeletal Diseases
Necrosis
Pathologic Processes
Alendronate
Bone Density Conservation Agents
Physiological Effects of Drugs