Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation
|Children With a Univentricular Heart Undergoing Surgery for Creation of a Fontan Circulation||Drug: Administration of an ACE-inhibitor or not||Phase 2|
|Study Design:||Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:||Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation|
- Duration of the pleural drainage in the first two postoperative weeks
|Study Start Date:||December 2002|
|Study Completion Date:||March 2007|
Children that are undergoing elective surgery for the creation of a Fontan circulation will be randomised to postoperative administration of an ACE-inhibitor or not.
Determination of aldosteron, renine and ADH in serum preoperatively and 1h, 12h and 5 days postoperatively.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00263406
|University Hospital Ghent|
|Ghent, Belgium, 9000|
|Principal Investigator:||Guy Van Nooten, MD, PhD||University Hospital, Ghent|