We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Diuretic Efficacy of Dexamethasone in Heart Failure

This study has suspended participant recruitment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00263302
First Posted: December 8, 2005
Last Update Posted: July 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hebei Medical University
  Purpose
The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.

Condition Intervention Phase
Heart Failure, Congestive Drug: dexamethasone Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Diuretic Efficacy of Dexamethasone in Congestive Heart Failure Patients

Resource links provided by NLM:


Further study details as provided by Hebei Medical University:

Primary Outcome Measures:
  • urine volume
  • urine electrolyte excretion (urine sodium, urine potassium, urine chloride), and urine creatinine.
  • serum electrolyte (serum sodium, serum potassium, serum chloride), serum creatinine, serum urea, serum uric Acid.
  • fractional sodium excretion
  • glomerular filtration rate (calculated by Cockroft and Gault formula).

Estimated Enrollment: 60
Study Start Date: March 2006
Estimated Study Completion Date: December 2006
Detailed Description:
Glucocorticoids are known to have pronounced physiological effects in the kidney. Conventional teaching dictates that it should be used with caution in patients with congestive heart failure due to its fluid and sodium retention effects. Surprisingly, despite the widespread prevalence of this belief within the medical community, there are few data to support it. In fact, several small animal studies have documented its striking diuretic effects due to increased renal plasma flow and glomerular filtration rate without changes in the glomerular filtration fraction. We design this study to determine whether glucocorticoids have a potent diuretic effect in patients with heart failure.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Congestive heart failure patients due to any cause
  • Patients with normal cortical function
  • Congestive heart failure patients who are on diuretic therapy
  • Clinically stable and body weight maintained the same for at least 3 days without signs of fluid retention

Exclusion Criteria:

  • Patient refusal
  • Signs of infection
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00263302


Locations
China, Hebei
Kunshen Liu
Shijiazhuang, Hebei, China, 050031
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050031
Sponsors and Collaborators
Hebei Medical University
Investigators
Study Chair: Kunshen Liu, M.D. Hebei Medical University
  More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00263302     History of Changes
Other Study ID Numbers: 0512-e
First Submitted: December 7, 2005
First Posted: December 8, 2005
Last Update Posted: July 4, 2008
Last Verified: January 2005

Keywords provided by Hebei Medical University:
dexamethasone, diuretic, congestive heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Dexamethasone acetate
Dexamethasone
BB 1101
Diuretics
Anti-Inflammatory Agents
Antiemetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Glucocorticoids
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents