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Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications

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ClinicalTrials.gov Identifier: NCT00260871
Recruitment Status : Unknown
Verified July 2011 by National Health Research Institutes, Taiwan.
Recruitment status was:  Active, not recruiting
First Posted : December 2, 2005
Last Update Posted : July 29, 2011
Information provided by:

Study Description
Brief Summary:
Lung adenocarcinoma in Chinese females is hypothesized to be determined by both genetic and environmental factors. In this grant proposal, we propose to map the loci of susceptibility genes of female lung adenocarcinoma based on multiplex families recruited in Taiwan. We focus on a unique pathological type of a unique population in order to reduce heterogeneity of the genetic background. Compared with western women, female Chinese population has a high prevalence of lung adenocarcinoma. Our reasoning is that if we focus on a specific sub-type, which has a familial basis, we will increase the probability of identifying genes associated with female lung adenocarcinoma. The primary goal of this study is to identify the genetic and environmental determinants of female lung adenocarcinoma, and study the relationship between gene polymorphisms and clinical manifestation profiling of lung cancer.

Condition or disease
Lung Cancer

Detailed Description:

This research proposal intends to integrate epidemiologists, biostatisticians, clinicians, molecular biologists/geneticists to identify susceptible genes for lung cancer, especially for female lung adenocarcinoma, and to study the relationship between gene polymorphisms and clinical outcomes of lung cancer patients. Our objective is to find gene markers for developing useful screening tools for the high risk group in order to prevent or early detect lung cancer, especially female lung adenocarcinoma.

The specific aims of this subproject include:

  1. Establish and maintain the research network that will recruit and follow up the subjects and families for the GEFLAC study; keeping control of the progress of the study.
  2. Coordinate all the subprojects such as integrating genotyping data with clinical data and environment data.
  3. Continue to employ the candidate gene approach to examine the contribution of specific genes to the lung cancer.
  4. Generate genotyping data for candidate genes in the exploring stage and prioritize SNPs of candidate genes for large scale studies.
  5. Identify susceptible genes/candidate genes to develop multiplex PCR for screening.

Study Design

Study Type : Observational
Estimated Enrollment : 1500 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications-focusing on Female Lung Adenocarcinoma (GEFLAC)
Study Start Date : May 2002

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Cancer
U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The program project intend to identify susceptible genes for lung cancer, especially for female lung adenocarcinoma.

Inclusion Criteria:

  • lung adenocarcinoma

Exclusion Criteria:

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00260871

Division of Biostatistics and Bioinformatics, NHRI
Miaoli county, Taiwan, 350
Sponsors and Collaborators
National Health Research Institutes, Taiwan
National Taiwan University Hospital
Taipei Veterans General Hospital, Taiwan
Chang Gung Memorial Hospital
Taichung Veterans General Hospital
National Cheng-Kung University Hospital
Kaohsiung Medical University
Study Director: Chao Hsiung, PhD NHRI
More Information

Additional Information:
Responsible Party: Dr. Chao Agnes Hsiung, Institute of Population Health Sciences, National Health Research Instiutes, Taiwan
ClinicalTrials.gov Identifier: NCT00260871     History of Changes
Other Study ID Numbers: 94LCP005
First Posted: December 2, 2005    Key Record Dates
Last Update Posted: July 29, 2011
Last Verified: July 2011

Keywords provided by National Health Research Institutes, Taiwan:
lung adenocarcinoma
genetic epidemiology
environmental factors
genetic map
coordination center

Additional relevant MeSH terms:
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases