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Brain Abnormalities in Late-Onset Major Depression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00260468
Recruitment Status : Completed
First Posted : December 1, 2005
Last Update Posted : October 22, 2009
The Danish Medical Research Council
Information provided by:
University of Aarhus

Brief Summary:
The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging (MRI), neuropsychological testing, neurological examination, eye examination as well as blood and saliva samples. The results are to be compared with results from a control group matched for gender and age.

Condition or disease Intervention/treatment
Major Depression Other: Clinical examination program

Detailed Description:

Major depression is a frequent and serious disorder with different prognoses and complications with respect to lack of treatment response, recurrence and suicide.

MRI of the brain can provide information about changes in the brain tissue with depression, e.g. lesions of nerve connections, small thrombi or changes in the blood flow. These changes appear primarily after the age of 50 and are seen in cases of diabetes and high blood pressure. Furthermore, the connection between disruptions in the body's stress response system and depression will be explored, which is very important since studies indicate that stress and depression can affect certain brain parts permanently. This will give us a better understanding of the connection between brain changes, neuropsychology and depression prognosis, which is decisive for accurate diagnostics, effective treatment and targeted prevention of the disease in the long run.

The project is part of a larger clinical assessment programme in the Neuropsychiatric Unit under the Centre for Basic Psychiatric Research, Aarhus Psychiatric Hospital, Denmark, which gives us unique possibilities of combining research and daily clinical work. The hope is in the future to be able to offer patients in the risk group better assessment and treatment to prevent complications and recurrence.

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Study Type : Observational
Actual Enrollment : 44 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Structural and Functional Cerebral Findings in Late-Onset Major Depression
Study Start Date : November 2005
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

Intervention Details:
  • Other: Clinical examination program
    Psychiatric/clinical interview MRI scan Blood samples Saliva samples Eye examination

Biospecimen Retention:   Samples With DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
  1. Subjects with first-episode late-onset major depression from psychiatric hospital or clinic
  2. Healthy controls

Inclusion Criteria:

  • first time major depression
  • age over 50 years
  • Caucasian
  • admitted at a psychiatric hospital or treated at a local psychiatric clinic in Aarhus Amt

Exclusion Criteria:

  • major brain damage (e.g. stroke, epilepsy, trauma)
  • major alcohol or drug abuse

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00260468

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Centre for Psychiatric Research, Aarhus University Hospital
Risskov, Denmark, DK-8240
Sponsors and Collaborators
University of Aarhus
The Danish Medical Research Council
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Study Director: Raben Rosenberg, Professor, MD, DrMedSc Aarhus University Hospital
Principal Investigator: Videbech Poul, Professor, MD, DrMedSc Aarhus University Hospital
Study Chair: Leif Østergaard, Professor, MD, DrMedSc, PhD Center for Functionally Integrative Neuroscience (CFIN), Aarhus University Hospital, Denmark
Additional Information:
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Responsible Party: Professor Poul Videbech, MD, DrMedSc, Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denamrk Identifier: NCT00260468    
Other Study ID Numbers: 20051050
First Posted: December 1, 2005    Key Record Dates
Last Update Posted: October 22, 2009
Last Verified: October 2009
Keywords provided by University of Aarhus:
Major depression
Magnetic resonance imaging
White matter lesions
Magnetization transfer
Vascular risk factors
Additional relevant MeSH terms:
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Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders