Aspirin Resistance Following Coronary Bypass Surgery

This study has been terminated.
(The researcher had left the hospital and the project was stopped)
Information provided by:
Sheba Medical Center Identifier:
First received: November 29, 2005
Last updated: September 8, 2008
Last verified: September 2008
Aspirin was proved to be the drug preventing vein grafts from closure and improving clinical outcome after coronary artery bypass surgery. It appears to be effective when being prescribed as early as first 48 hr. after the operation without increasing the incidence of bleeding complications. the exact effective dose is not known.

Condition Intervention
Ischemic Heart Disease
Procedure: Coronary artery bypass surgery

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Primary Outcome Measures:
  • Ventilation
  • Inotropic support
  • Mortality
  • Perioperative MI
  • Perioperative stroke
  • Bleeding / reopen / transfusion
  • Dysrhythmias

Secondary Outcome Measures:
  • ICU stay
  • In-hospital stay
  • Non-fatal cardiac events - MI, recurrence of angina, dysrhythmias
  • Need for repeat revascularization

Study Start Date: January 2005
Estimated Study Completion Date: December 2006
Estimated Primary Completion Date: June 2006 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   30 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients undergoing Coronary artery bypass surgery
  • Patients who signed Informed Consent Form

Exclusion Criteria:

  • Concomitant valve surgery or carotid surgery or off-pump surgery
  • Need for anticoagulation therapy for any reason
  • Another antiplatelet medications at least 7 days prior to surgery
  • Contra-indication for aspirin treatment
  • Thrombocytopenia / thrombocytopathia
  • NSAIDs treatment for chronic medical conditions
  • Reluctance to participate in the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00260377

Sheba Medical Center
Ramat-Gan, Israel
Sponsors and Collaborators
Sheba Medical Center
Principal Investigator: Jacob Lavee, Dr
  More Information Identifier: NCT00260377     History of Changes
Other Study ID Numbers: SHEBA-03-3107-JL-CTIL 
Study First Received: November 29, 2005
Last Updated: September 8, 2008
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:
Aspirin treatment
Aspirin resistance
Coronary bypass surgery

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Coronary Disease
Heart Diseases
Vascular Diseases processed this record on May 30, 2016