Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers
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Tis study was designed to test the hypothesis that pretreatment with valdecoxib, prior to injury could reduce or prevent the development of secondary hyperalgesia around the area of primary injury. A heat/capsaicin model of induced hyperalgesia was tested in healthy volunteers in a randomized, double blind, cross-over trial of a single dose of 40 mg vadecoxib versus control. Subjects rated pain intesnsity and unpleasantness following heat stimulation of the forearm, the area of hyperalgesia was also mapped over the course of the experiment.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
healthy male of non-pregnant female; 18yo or older
not currently taking NSAID
able and willing to provide informed consent
willing to avoid other NSAIDs in 24 hour period following study
no known hypersentitivites or contraindications to NSAIDS, sulfonomides or capsaicin
pregnant or breast feeding
use of NSAIDS or other analgesic medications in past 7 days
unwilling or unable to give informed consent
contraindication to any study medication or other NSAID