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Food Rheology and Feeding in Lean and Obese Humans

This study has been completed.
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
Richard Mattes, Purdue University
ClinicalTrials.gov Identifier:
NCT00260130
First received: November 29, 2005
Last updated: May 28, 2013
Last verified: May 2013
  Purpose
The 2010 National Health Objectives call for a reduction in the prevalence of obesity. The marked recent increase in overweight and obesity prevalence implicates behavioral factors in the etiology of the epidemic. The present proposal hypothesizes the trend is attributal, in part, to increasing consumption of energy-yeilding beverages since they are a significant and increasing source of dietarty energy and they elicit weaker appetitive and dietary responses than solid foods.

Condition Intervention
Obesity
Overweight
Diabetes
Other: food in fluid form
Other: food in solid form

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Official Title: Study 1: Viscosity Study Study 2: Meal Timing Study Study 3:Chronic Fluid and Solid Food Intake in Lean and Overweight Individuals

Further study details as provided by Purdue University:

Primary Outcome Measures:
  • satiation and satiety on liquid verses solid foods with concurrent measurements of appetite, dietary intake, energy expenditure and body weight/composition. [ Time Frame: 8 weeks ]

Secondary Outcome Measures:
  • cephalic phase testing at week 8 [ Time Frame: 30 minutes ]

Estimated Enrollment: 34
Study Start Date: February 2005
Study Completion Date: July 2009
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Consuming fruit and vegetable juice
Other: food in fluid form
dietary intake of fluid forms of vegetables
Active Comparator: 2
Consuming whole fruits and vegetables
Other: food in solid form
dietary intake of solid forms of vegetables

Detailed Description:
Three human studies are propsed to more fully characterized attributes of liquids and solids that may account for the differential appetitive responses they elicit, potential contributory mechanisms as well as the dietary implications of their consumption. Study 1 will contrast the acute effects of fluid and solid foods varying in macronutrient content on satiation, satiety and feeding. Study 2 will determine if the pattern of fluid and solid ingestion influences satiety and feeding by monitoring appetitive and dietary responses to energy and macronutrient matched fluid and solid loads ingested as meal components or between meal snacks. To better assess the clinical implications ofdiets incorpprating liquid or solid supplements. Study 3 will entail chronic ingestion of matched energy yeilding fluid or solid loads with concurrent measurement of appetite, dietary intake, energy expenditureand body weight/composition.
  Eligibility

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 18-23 or 27-35
  • weight stable
  • constant habitual activity pattern
  • low fruit/vegetable consumer
  • non-restrained eater

Exclusion Criteria:

  • diabetic
  • taking medication known to influence appetite
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00260130

Locations
United States, Indiana
Purdue University
West Lafayette, Indiana, United States, 47906
Sponsors and Collaborators
Purdue University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: Richard D Mattes, MPH, PhD, RD Purdue University
  More Information

Additional Information:
Responsible Party: Richard Mattes, Prof. Foods and Nutrition, Purdue University
ClinicalTrials.gov Identifier: NCT00260130     History of Changes
Other Study ID Numbers: DK63185 (completed)
R01DK063185 ( US NIH Grant/Contract Award Number )
Study 1: 503001275
Study 2: 508002908
Study 3: 505002589
Study First Received: November 29, 2005
Last Updated: May 28, 2013

Keywords provided by Purdue University:
obesity
food intake
human
energy balance
beverage

Additional relevant MeSH terms:
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on April 26, 2017