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Risk Factors of Individuals With Coronary Artery Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2008 by Nanjing Medical University.
Recruitment status was:  Recruiting
Information provided by:
Nanjing Medical University Identifier:
First received: November 29, 2005
Last updated: May 23, 2008
Last verified: May 2008
It would be useful to study coronary arteriovenous difference of various markers in patients who are undergoing coronary angiography for suspected coronary artery disease. Environmental and genetic factors may play a role in the progression of coronary artery disease. The goal of this project is to establish a series of cross-sectional / case-control studies to evaluate risk factors of coronary artery disease in China.

Coronary Artery Disease

Study Type: Observational
Study Design: Time Perspective: Retrospective

Resource links provided by NLM:

Further study details as provided by Nanjing Medical University:

Study Start Date: November 2005
Detailed Description:
This study is designed to investigate the epidemiologic, genetic, laboratory and clinical characterization of individuals with coronary artery disease. The study group will consist of consecutive patients who are undergoing coronary angiography for suspected coronary artery disease. The diagnosis of coronary artery disease will be confirmed by coronary angiography performed with the Judkins technique using a quantitative coronary angiographic system. Coronary artery disease will be considered to be present if there is a diameter stenosis of at least 50% in at least one of the three major epicardial coronary arteries. The number of diseased vessels will be determined and a classification of 1-, 2-, and 3-vessel disease will be used. Coronary artery segments will be defined according to the Coronary Artery Surgery Study classification. Blood samples from vein and coronary artery will be collected. We will study coronary arteriovenous difference of various markers. Urinary samples will be obtained the day of coronary angiography. We will explore the environmental (including family history, life style, diet, physical activity, neuropsychological functioning,plasma levels of oxidative stress factors, angiogenic factors, and inflammatory markers, etc.) and genetic (including oxidative stress factors and inflammatory factors, etc.) risk factors. We will study the association between various environmental risk factors with the clinical characterization and correlation between the genetic polymorphisms and the presence of coronary artery disease.

Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • This is a study only of Chinese.
  • Subjects will be allowed to participate if they self-identify as Chinese.
  • The age range of the participants will be between 18 and 89 years.
  • The study group will consist of consecutive patients who are undergoing coronary angiography for suspected coronary artery disease.

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00260104

Contact: Bin Wang, Ph.D 0086-25-86862884

Nanjing Medical University Recruiting
Nanjing, China, 210029
Sponsors and Collaborators
Nanjing Medical University
Principal Investigator: Bin Wang, Ph.D Department of Pharmacology, Institute of Clinical Pharmacology, Nanjing Medical University
  More Information

Publications: Identifier: NCT00260104     History of Changes
Other Study ID Numbers: ICP058
Study First Received: November 29, 2005
Last Updated: May 23, 2008

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on May 24, 2017