In-patient Study in Patients With Type 2 Diabetes Mellitus
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This study is a placebo-controlled study in both healthy normal subjects and patients with Type 2 Diabetes Mellitus to assess the levels of exenatide in the bloodstream when it is given for 7 days, and to assess the impact this medication has on various substances in the blood. Assessments include repeat blood sampling and monitoring of any side effects.
A Randomized, Open-label, Placebo-controlled, Repeat-dose Study to Assess the Pharmacokinetics and Pharmacodynamics of 5 Micrograms Exenatide Administered Subcutaneously Twice Daily for 7 Days in Healthy Normal Volunteers and in Subjects With Type 2 Diabetes Mellitus
Study Start Date :
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Ages Eligible for Study:
18 Years to 66 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
have type 2 diabetes mellitus that has been diagnosed for at least three months
must be taking either (1) no medication for their diabetes or (2) taking metformin, a sulfonylurea, or metformin and a sulfonylurea
must be willing to wash-out of these medications for 14 days prior to the start of the study
must have bloodwork that meets certain criteria (for example, total cholesterol < 240 mg/dL)
must not have any other major illness other than diabetes