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Microvascular Reactivity.

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00259701
First Posted: November 29, 2005
Last Update Posted: October 6, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Yale University
  Purpose
This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Condition Intervention
Diabetes Retinopathy Vascular Pathology Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Resource links provided by NLM:


Further study details as provided by Yale University:

Estimated Enrollment: 20
Study Start Date: June 2005
Estimated Study Completion Date: September 2005
Detailed Description:
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00259701


Locations
United States, Connecticut
Yale School of Medicine
New HAven, Connecticut, United States, 06510
Sponsors and Collaborators
Yale University
Investigators
Principal Investigator: David G Silverman Yale School of Medicine
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00259701     History of Changes
Other Study ID Numbers: HIC-12397-1
First Submitted: November 28, 2005
First Posted: November 29, 2005
Last Update Posted: October 6, 2006
Last Verified: November 2005

Keywords provided by Yale University:
endothelium
iontophoresis
acetylcholine
nitroglycerin
vasodilation

Additional relevant MeSH terms:
Nitroglycerin
Acetylcholine
Vasodilator Agents
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs