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Microvascular Reactivity.

This study has been completed.
Information provided by:
Yale University Identifier:
First received: November 28, 2005
Last updated: October 5, 2006
Last verified: November 2005
This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Condition Intervention
Diabetes Retinopathy Vascular Pathology Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Resource links provided by NLM:

Further study details as provided by Yale University:

Estimated Enrollment: 20
Study Start Date: June 2005
Estimated Study Completion Date: September 2005
Detailed Description:
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

  Contacts and Locations
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Please refer to this study by its identifier: NCT00259701

United States, Connecticut
Yale School of Medicine
New HAven, Connecticut, United States, 06510
Sponsors and Collaborators
Yale University
Principal Investigator: David G Silverman Yale School of Medicine
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00259701     History of Changes
Other Study ID Numbers: HIC-12397-1
Study First Received: November 28, 2005
Last Updated: October 5, 2006

Keywords provided by Yale University:

Additional relevant MeSH terms:
Vasodilator Agents
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on June 23, 2017