Functional Lipids and Appetite Regulation
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|ClinicalTrials.gov Identifier: NCT00259259|
Recruitment Status : Completed
First Posted : November 29, 2005
Last Update Posted : January 21, 2009
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Behavioral: SALATRIM||Not Applicable|
Background Obesity is a major health problem worldwide, and it is a risk factor for several chronic disorders. Even small changes in energy intake, leading to a positive balance may lead to weight gain over time. Thus, slight modifications in food intake, such as the inclusion of foods that effect energy balance, may prevent weight gain and even facilitate weight loss. Replacing dietary fat with low-calorie fat (LCF), such as modified triglycerides with medium and long chained PUFA.may be an efficient way to reduce body fat.
Bray et al. (2002) has shown a sustained weight loss of ~6 kg over a 9 month period where one-third of a fat-reduced diet (25% fat) was replaced by olestra. This weight loss can not solely be explained by the decreased caloric content of olestra. Thus, inhibition of appetite leading to lower food intake, may be a potential mechanism of the observed weight loss.
A reduced absorption of LCF leaves undigested fatty acids in the middle and lower intestine, which may generate increased feelings of satiety and decrease caloric intake due to regulating peptides and hormones such (CCK, GLP-1, etc.). In addition, intraduodenal fatty acids may also promote distension of the stomach and distension of the intestine, which are well-known gastrointestinal signals controlling mechanisms for food intake.
Taken together, in addition to the acute reduction in caloric intake, LCF may encourage a gastrointestinal hormone response promoting beneficial effects on appetite regulation and energy balance.
Aims To evaluate the short-term effects of LCF on
- Appetite sensations after a meal (VAS)
- Postprandiel secretion of appetite regulating hormones
- Ad libitum caloric intake 4,5-h subsequent to a fixed meal
• Palatability of the test meal
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||The Effect of Functional Lipids on Appetite Regulation in Man|
|Study Start Date :||October 2005|
|Study Completion Date :||December 2005|
- energy intake
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00259259
|Department of Human Nutrition, The Royal Veterinary and Agricultural University|
|Frederiksberg C, Copenhagen, Denmark, 1958|
|Principal Investigator:||Arne Astrup, Proffessor||Department of human nutrition, The Royal Veterinary and Agricultural University|