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A Protocol for the Use of Chlorhexidine Gluconate Saturation for the Reduction of Dental Biofilm Formation on Polymethylmethacrylate Restoration

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00259181
First Posted: November 29, 2005
Last Update Posted: January 6, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hadassah Medical Organization
  Purpose
Chlorhexidine gluconate (CHX), as an anti plaque agent, is commonly used with a variety of products. In this study we, the investigators at Hadassah Medical Organization, intend to examine the efficacy of a single dip in CHX of provisional restoration prior to oral cementation. If the protocol is effective, we intend to calibrate it and recommend clinical use of the protocol. The examination of biofilm formation will be both with electron microscope and confocal scanning laser microscope.

Condition Intervention Phase
Dental Plaque Procedure: saturation of polymethylmethacrylate with chlorhexidine gluconate to reduce in vivo plaque formation Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single
Primary Purpose: Prevention
Official Title: Examination of the Immersion of Provisional Crown Material in Chlorhexidine Gluconate on Dental Plaque Formation in Vivo

Resource links provided by NLM:


Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • calibration of a preventative protocol for biofilm formation measured by confocal scanning laser microscope and scanning electron microscope

Estimated Enrollment: 12
Study Start Date: January 2005
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Any volunteer without systemic condition

Exclusion Criteria:

  • Intake of antibiotic drug three months prior to experiment
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00259181


Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel, 91120
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Study Director: Michael M Perez Davidi, DMD Hadassah Medical Organization
  More Information

ClinicalTrials.gov Identifier: NCT00259181     History of Changes
Other Study ID Numbers: 191058HMO-CTIL
First Submitted: November 24, 2005
First Posted: November 29, 2005
Last Update Posted: January 6, 2010
Last Verified: December 2007

Keywords provided by Hadassah Medical Organization:
chlorhexidine gluconate
polymethylmethacrylate
Anti-Bacterial Agents

Additional relevant MeSH terms:
Dental Plaque
Dental Deposits
Tooth Diseases
Stomatognathic Diseases
Chlorhexidine
Chlorhexidine gluconate
Polymethyl Methacrylate
Anti-Infective Agents, Local
Anti-Infective Agents
Disinfectants
Dermatologic Agents
Vasodilator Agents
Antimutagenic Agents
Protective Agents
Physiological Effects of Drugs