Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00257985|
Recruitment Status : Completed
First Posted : November 24, 2005
Last Update Posted : August 1, 2006
|Condition or disease||Intervention/treatment|
|Familial Hemiplegic Migraine Type 1 and 2 Healthy Volunteers||Drug: GTN|
Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous attacks in approximately 80% of migraine sufferers. After systemic administration GTN is transformed to nitric oxide (NO). Treatment of spontaneous migraine attacks with an inhibitor of NO is effective in 60% of patients. These data show that NO is involved in both initiation and maintenance of migraine attack.
The consequence of migraine gene mutations on relevant migraine pathways has never been tested. The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion. The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Official Title:||Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2|
|Study Start Date :||April 2005|
|Estimated Study Completion Date :||March 2006|
- headache and associated symptoms , blood flow velocity of the middle cerebral artery, diameter of the superficial temporal artery
- MAP, HR
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00257985
|Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital|
|Glostrup, Copenhagen, Denmark, DK-2600|
|Principal Investigator:||Jakob Møller Hansen, MD||Danish Headache Center|