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Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
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Purpose
| Condition | Intervention |
|---|---|
| Familial Hemiplegic Migraine Type 1 and 2 Healthy Volunteers | Drug: GTN |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: Single Blind Primary Purpose: Educational/Counseling/Training |
| Official Title: | Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 |
- headache and associated symptoms , blood flow velocity of the middle cerebral artery, diameter of the superficial temporal artery
- MAP, HR
| Estimated Enrollment: | 30 |
| Study Start Date: | April 2005 |
| Estimated Study Completion Date: | March 2006 |
Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous attacks in approximately 80% of migraine sufferers. After systemic administration GTN is transformed to nitric oxide (NO). Treatment of spontaneous migraine attacks with an inhibitor of NO is effective in 60% of patients. These data show that NO is involved in both initiation and maintenance of migraine attack.
The consequence of migraine gene mutations on relevant migraine pathways has never been tested. The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion. The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets.
Eligibility| Ages Eligible for Study: | Child, Adult, Senior |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Patients: Diagnosis of familial hemiplegic migraine (IHS-classification criteria) caused by mutations in the CACNA1A gene and the ATP1A2 gene.
Controls: healthy volunteers
Exclusion Criteria:
Controls: No primary headache in their own history
Patients and controls:
- A history of cerebrovascular disease and other CNS- disease
- A history of serious somatic and mental disease
- A history suggesting ischaemic heart disease
- A history of hypo- or hypertension
- Daily intake of medication apart from oral contraceptives
- Abuse of alcohol or medicine (opioid analgesics).
- Pregnant or breastfeeding women.
On the study day:
- No intake of a simple analgesic in the previous 48 hours
- No headache in the previous 48 hours
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00257985
| Denmark | |
| Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital | |
| Glostrup, Copenhagen, Denmark, DK-2600 | |
| Principal Investigator: | Jakob Møller Hansen, MD | Danish Headache Center |
More Information
| ClinicalTrials.gov Identifier: | NCT00257985 History of Changes |
| Other Study ID Numbers: |
FHM-GTN 2005 |
| Study First Received: | November 22, 2005 |
| Last Updated: | July 31, 2006 |
Keywords provided by Danish Headache Center:
|
Familial hemiplegic migraine type 1 and 2 GTN middle cerebral artery |
superficial temporal artery headache genotype |
Additional relevant MeSH terms:
|
Migraine Disorders Headache Migraine with Aura Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases |
Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms Nitroglycerin Vasodilator Agents |
ClinicalTrials.gov processed this record on July 18, 2017