Inflammation and the Host Response to Injury (Trauma)
This study is ongoing, but not recruiting participants.
First Posted: November 22, 2005
Last Update Posted: November 9, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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Information provided by (Responsible Party):
Ronald G. Tompkins, Massachusetts General Hospital
The purpose of this study is to help improve our understanding of the biology involved in the body's response to serious trauma or burn injury. The host response to trauma and burns is a collection of physiological and pathophysiological processes that depend critically upon the regulation of the human innate immune system, with particular emphasis on the inflammatory component of that system. No single research center or small group of centers has the capacity to delineate the integrated response of this complex biological system, which involves multiple molecular and genetic interactions that vary in time. Our proposal promotes the identification of important dynamic relationships that regulate the integration of this complex biological system, with the expectation that this understanding will ultimately impact the diagnosis, prognosis, and treatment of the hospitalized, severely injured patient.
Multiple Organ Failure
||Observational Model: Cohort
Time Perspective: Prospective
||Inflammation and the Host Response to Injury
Biospecimen Retention: Samples Without DNA
Primary Outcome Measures:
- Time to death [ Time Frame: Within 28 after trauma injury ]
- Change in gene expression after trauma injury [ Time Frame: Up to 28 days after trauma injury ]
- Number and types of complications [ Time Frame: Up to 28 days after trauma injury ]
Plasma, blood leukocyte nucleic acids (only RNA, no DNA)
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
| Primary Completion Date:
||September 2013 (Final data collection date for primary outcome measure)
This large-scale collaborative project provides the means to acquire the necessary new knowledge directly in humans. Knowledge will be acquired using diverse state-of-the-art genomic and proteomic technologies, a highly complex clinical, proteomic, and genomic database, as well as newly-developed, novel analytical tools to probe this complex dataset. Our analytical capabilities at the genomic and proteomic level are now rapidly evolving and our ability to link these genomic and proteomic data to pathways and functional modules will help us more closely link this cellular data to immunological processes and ultimately, to the phenotypic response (i.e., trajectory) in the injured host. As a result, potential interventions, whether through our Program or other funding mechanisms, can be more effectively designed.