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Trial record 8 of 46 for:    Dyslexia

Morphofunctional Imaging and Developmental Dyslexia (PHR04-CH/DYS)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Tours Identifier:
First received: November 15, 2005
Last updated: January 13, 2017
Last verified: May 2011
Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.

Condition Intervention
Developmental Dyslexia
Procedure: Morphological and functional MRI

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Morphofunctional Imaging and Developmental Dyslexia

Further study details as provided by University Hospital, Tours:

Primary Outcome Measures:
  • Cortical thickness [ Time Frame: 2 years ]
    The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages

Secondary Outcome Measures:
  • Average cortical thickness [ Time Frame: 2 years ]
    For each group, cortical thickness maps of average left and right hemispheres are compared. This will identify whether there is an asymmetry left / right in terms of cortical thickness in normal subjects and dyslexic.

Enrollment: 32
Study Start Date: February 2007
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
This is a prospective study including 15 right-handed male subjects, aged 18 to 35 years, carrying a developmental dyslexia and 15 control subjects handed the same sex. We chose to include only male subjects to obtain a homogeneous population and to avoid the problem of a functional organization differs according to gender.

Inclusion Criteria:

  • Developmental dyslexia according to Critchley.
  • Normal performance intelligence quotient (PIQ)
  • Age: 18-35 years
  • Sex: Male
  • Right handed
  • No hearing deficit.

Exclusion Criteria:

  • No head injury
  • No attention deficit hyperactivity disorder (ADHD)
  Contacts and Locations
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Please refer to this study by its identifier: NCT00254644

Tours, France, 37044
Sponsors and Collaborators
University Hospital, Tours
Principal Investigator: Frédérique Bonnet-Brilhault CHU Tours
  More Information

Responsible Party: University Hospital, Tours Identifier: NCT00254644     History of Changes
Other Study ID Numbers: PHRR04-CH/DYS
Study First Received: November 15, 2005
Last Updated: January 13, 2017

Keywords provided by University Hospital, Tours:
phonological treatment

Additional relevant MeSH terms:
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Neurodevelopmental Disorders
Mental Disorders processed this record on May 24, 2017