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Morphofunctional Imaging and Developmental Dyslexia (PHR04-CH/DYS)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00254644
First Posted: November 16, 2005
Last Update Posted: January 16, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University Hospital, Tours
  Purpose
Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.

Condition Intervention
Developmental Dyslexia Procedure: Morphological and functional MRI

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Morphofunctional Imaging and Developmental Dyslexia

Further study details as provided by University Hospital, Tours:

Primary Outcome Measures:
  • Cortical thickness [ Time Frame: 2 years ]
    The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages


Secondary Outcome Measures:
  • Average cortical thickness [ Time Frame: 2 years ]
    For each group, cortical thickness maps of average left and right hemispheres are compared. This will identify whether there is an asymmetry left / right in terms of cortical thickness in normal subjects and dyslexic.


Enrollment: 32
Study Start Date: February 2007
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Dyslexia
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time
Control
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
This is a prospective study including 15 right-handed male subjects, aged 18 to 35 years, carrying a developmental dyslexia and 15 control subjects handed the same sex. We chose to include only male subjects to obtain a homogeneous population and to avoid the problem of a functional organization differs according to gender.
Criteria

Inclusion Criteria:

  • Developmental dyslexia according to Critchley.
  • Normal performance intelligence quotient (PIQ)
  • Age: 18-35 years
  • Sex: Male
  • Right handed
  • No hearing deficit.

Exclusion Criteria:

  • No head injury
  • No attention deficit hyperactivity disorder (ADHD)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00254644


Locations
France
CHU
Tours, France, 37044
Sponsors and Collaborators
University Hospital, Tours
Investigators
Principal Investigator: Frédérique Bonnet-Brilhault CHU Tours
  More Information

Responsible Party: University Hospital, Tours
ClinicalTrials.gov Identifier: NCT00254644     History of Changes
Other Study ID Numbers: PHRR04-CH/DYS
First Submitted: November 15, 2005
First Posted: November 16, 2005
Last Update Posted: January 16, 2017
Last Verified: May 2011

Keywords provided by University Hospital, Tours:
phonological treatment
language
fMRI

Additional relevant MeSH terms:
Dyslexia
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Neurodevelopmental Disorders
Mental Disorders