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A Brain Imaging Study of Nicotine Release in Cigarette Smokers

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ClinicalTrials.gov Identifier: NCT00254358
Recruitment Status : Terminated (It was decided to use a different protocol with a different radioligand)
First Posted : November 16, 2005
Last Update Posted : July 4, 2008
Sponsor:
Collaborator:
Herzog Hospital
Information provided by:
Hadassah Medical Organization

Brief Summary:
Tobacco Smoking is the most prevalent addiction in society today causing directly major health hazards and sharing morbidity with other psychiatric disorders. Nicotine binds to acetylcholine receptors and thus elevates DA release and inhibits DA transport. There are few studies using advanced brain imaging techniques to investigate how nicotine releases dopamine in humans. These studies utilized dopamine displacement paradigms with [11C] Raclopride binding to D2 receptor in Positron Emission Tomography (PET). There is evidence that smokers (particularly those who enjoyed smoking) showed decreased [11C] Raclopride binding in the caudate/nucleus accumbens and putamen after smoking cigarettes. These results also indicated that the effects of nicotine on dopaminergic neurotransmission are mediated by pleasure and craving. We propose to investigate the effects of smoking a cigarette ad lib on dopamine release by using dopamine competition paradigm with [I123] IBZM in SPECT. Secondly, we will test the hypothesis that dopamine deficiency is a major vulnerability factor for smoking. This may provide further evidence that dopamine deficiency in some smokers pre-disposes them to enjoy and desire smoking cigarettes more than others.

Condition or disease
Nicotine Dependence

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: A Brain Imaging Study of Nicotine Release in Cigarette Smokers
Study Start Date : April 2007
Actual Study Completion Date : April 2007

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Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
smokers in treatment with bupropion
Criteria

Inclusion Criteria:

  • Chronic smokers and healthy non-smokers.

Exclusion Criteria:

  • Pregnant and breast feeding women.
  • Age below 20.
  • Neurological disorders.
  • Others drugs.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00254358


Sponsors and Collaborators
Hadassah Medical Organization
Herzog Hospital
Investigators
Principal Investigator: Yodphat Krausz, MD Hadassah Medical Organization

Responsible Party: Dr. Aviv Weinstein, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00254358     History of Changes
Other Study ID Numbers: 842902-HMO-CTIL
First Posted: November 16, 2005    Key Record Dates
Last Update Posted: July 4, 2008
Last Verified: June 2008

Keywords provided by Hadassah Medical Organization:
Nicotine
Dopamine
IBZM

Additional relevant MeSH terms:
Tobacco Use Disorder
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Nicotine
Ganglionic Stimulants
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Nicotinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action