Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00253006|
Recruitment Status : Terminated
First Posted : November 15, 2005
Last Update Posted : October 9, 2006
Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes in many tissues.
The goal of this study is to illuminate bladder tissue production of NO in individuals with PBS and healthy individuals, by quantification of NO and NO-enzyme expression by different molecular biological methods.
|Condition or disease||Intervention/treatment|
|Interstitial Cystitis Bladder Diseases Urinary Incontinence||Procedure: Tissue examination for protein- and mRNA-expression of NO|
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||A Quantitative Analysis of Protein- and mRNA-Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium|
|Study Start Date :||January 2006|
|Estimated Study Completion Date :||January 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00253006
|Copenhagen University Hospital at Herlev|
|Herlev, Denmark, DK- 2730|
|Study Director:||Pierre Bouchelouche, MD||Roskilde County University Hospital at Koege, Dept. of Clinical Biochemistry|