Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder
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|ClinicalTrials.gov Identifier: NCT00252044|
Recruitment Status : Unknown
Verified November 2005 by Bronx VA Medical Center.
Recruitment status was: Recruiting
First Posted : November 11, 2005
Last Update Posted : November 21, 2005
Hypothesis: Schizotypal personality disorder patients will show cognitive improvements in 1) working memory 2) learning and memory 3) sustained attention 4) enhanced performance on the AX-CPT, N-back and Eriksen during pergolide treatment. There will be a significant diagnosis by drug administration of 0.3 mg of oral pergolide interaction for performance on the cognitive tasks, with the schizotypal personality disorder group demonstrating significantly improved peformance compared to the other personality disorder group after pergolide compared with placebo.
Design: Randomized, double-blind, crossover study of pergolide vs. placebo. Half of subjects receive pergolide for eight weeks; half of subjects receive placebo for four weeks followed by pergolide for four weeks.
|Condition or disease||Intervention/treatment||Phase|
|Schizotypal Personality Disorder Other Personality Disorders||Drug: Pergolide||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Intervention Model:||Crossover Assignment|
|Official Title:||The Dopaminergic System in Schizotypal Personality Disorder: Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder|
|Study Start Date :||October 2000|
- Performance on tests of sustained attention, episodic memory and working memory at baseline and after 2, 4, 6 and 8 weeks on the study medication
- Hamilton Depression Rating Scale, Positive and Negative Symptom Scale and Clinical Global Impression scale at baseline and then weekly through the end of the trial
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00252044
|Contact: Emily Hartfirstname.lastname@example.org|
|United States, New York|
|Mount Sinai School of Medicine||Recruiting|
|New York, New York, United States, 10029|
|Principal Investigator:||Larry J Siever, MD||Bronx VA Medical Center/Mount Sinai School of Medicine|