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Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00251615
First Posted: November 10, 2005
Last Update Posted: August 6, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )
  Purpose
The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.

Condition
Atherosclerosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) ):

Biospecimen Retention:   Samples With DNA
Vascular tissue obtained from the surgical site that would have otherwise been discarded and Blood Serum

Enrollment: 18
Study Start Date: August 2012
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Detailed Description:

The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments.

Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients scheduled for vascular surgery
Criteria

Inclusion Criteria:

  • Ages 21 and older
  • Scheduled for vascular surgery

Exclusion Criteria:

  • Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
  • Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
  • Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney [DPA]) for the volunteer, with the volunteer's assent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00251615


Locations
United States, Maryland
National Institute on Aging, Harbor Hospital
Baltimore, Maryland, United States, 21225
Sponsors and Collaborators
National Institute on Aging (NIA)
Investigators
Principal Investigator: Samer Najjar, MD National Institute on Aging (NIA)
  More Information

Publications:
Responsible Party: National Institute on Aging (NIA)
ClinicalTrials.gov Identifier: NCT00251615     History of Changes
Other Study ID Numbers: AG0058
First Submitted: November 8, 2005
First Posted: November 10, 2005
Last Update Posted: August 6, 2012
Last Verified: August 2012

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) ):
vascular surgery
vascular aging
arterial aging
surgical tissue
Aging

Additional relevant MeSH terms:
Cardiovascular Diseases
Atherosclerosis
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases