Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants
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Preterm infants are at risk to develop nephrocalcinosis. Incidence numbers vary according to birth weight and gestation age. Very low birth weight infants have the highest risk index, with ~ 7-10 % of preterm infants developing nephrocalcinosis in the patient population. We, the researchers at the University of Cologne, and others found significantly decreased urinary citrate excretion (hypocitraturia) to be one of the main risk factors. Hence, we hypothesized, that prophylactic treatment with oral alkaline citrate solution (Shol's solution) would help to 1) increase urinary citrate excretion and 2) help to decrease the incidence of nephrocalcinosis.
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Ages Eligible for Study:
up to 8 Weeks (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Preterm infants < 32 weeks gestation age and < 1500 g birth weight
Cardial, renal or gastrointestinal malformations
Chronic renal failure
Therapy with vitamin B6
High dose treatment with furosemide or dexamethasone
Severe metabolic alkalosis
Worse clinical condition of preterm infant, which makes oral feeding impossible