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Epidemiologic, Laboratory, and Clinical Characterization of Individuals With Ocular Diseases

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ClinicalTrials.gov Identifier: NCT00249392
Recruitment Status : Unknown
Verified May 2008 by Nanjing Medical University.
Recruitment status was:  Active, not recruiting
First Posted : November 7, 2005
Last Update Posted : May 23, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
Environmental and genetic factors may play a role in the progression of ocular diseases (cataract, retinopathy, age-related macular degeneration, glaucoma, retinal detachment, ocular tumor, etc.). The goal of this project is to establish a series of case-control studies to evaluate risk factors of ocular diseases in China.

Condition or disease
Ocular Diseases

Detailed Description:
This study is designed to investigate the epidemiologic, genetic, laboratory and clinical characterization of individuals with ocular diseases (cataract, retinopathy, age-related macular degeneration, glaucoma, retinal detachment, ocular tumor, etc.). We will accrue approximately 800 patients as experimental group. The control group consists of age/sex frequency-matched subjects who will be confirmed without ocular diseases. We will explore the environmental (including family history, life style, diet, physical activity, neuropsychological functioning,plasma levels of oxidative stress and angiogenic factors, etc.) and genetic (including oxidative stress and angiogenic factors, etc.) risk factors. We will study the association between various environmental risk factors with the clinical characterization and correlation between the genetic polymorphisms and the presence of various ocular diseases.

Study Design

Study Type : Observational
Estimated Enrollment : 800 participants
Study Start Date : October 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Eye Care
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • This is a study only of Chinese.
  • Subjects will be allowed to participate if they self-identify as Chinese.
  • Individuals with ocular diseases (cataract, retinopathy, age-related macular degeneration, glaucoma, retinal detachment, ocular tumor, etc.) will be allowed to participate. To participate in the study as the control, subjects should be confirmed without ocular diseases.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00249392


Locations
China, Jiangsu
Department of Pharmacology, Institute of Clinical Pharmacology, Nanjing Medical University
Nanjing, Jiangsu, China, 210029
Sponsors and Collaborators
Nanjing Medical University
Investigators
Principal Investigator: Bin Wang, Ph.D Department of Pharmacology, Institute of Clinical Pharmacology, Nanjing Medical University
More Information

ClinicalTrials.gov Identifier: NCT00249392     History of Changes
Other Study ID Numbers: ICP008
First Posted: November 7, 2005    Key Record Dates
Last Update Posted: May 23, 2008
Last Verified: May 2008

Keywords provided by Nanjing Medical University:
ocular diseases
risk factors
genetic factors