The Genetic Basis for Vulnerability to Substance Abuse
|Study Design:||Time Perspective: Prospective|
|Official Title:||Allelic Linkage in Substance Abuse|
|Study Start Date:||August 1992|
|Study Completion Date:||February 2006|
|Primary Completion Date:||February 2006 (Final data collection date for primary outcome measure)|
Dopamine (DA), a neurotransmitter helping to mediate reward and reinforcement, has been putatively linked to the development of substance abuse, alcohol abuse, and alcoholism. Identification of specific vulnerability-association alleles for receptors, other molecules within the reward mediating system, and other genes that may predispose individuals to the development of such disorders is the goal of the study.
This investigation will help elucidate the genetic underpinnings of substance abuse, potentially leading to the improved methods to diagnose those at risk and to help develop better therapeutic interventions.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00247819
|United States, Maryland|
|National Institute on Drug Abuse|
|Baltimore, Maryland, United States, 21224|
|Principal Investigator:||George Uhl, M.D., Ph.D.||National Institute on Drug Abuse (NIDA)|