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Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00247533
Recruitment Status : Unknown
Verified August 2005 by Far Eastern Memorial Hospital.
Recruitment status was:  Recruiting
First Posted : November 2, 2005
Last Update Posted : February 9, 2009
Information provided by:
Far Eastern Memorial Hospital

Brief Summary:

There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass surgery (CABG) or percutaneous coronary intervention. Perfusion defect on nuclear brain scan is also noted to correlate with these neurological complications. On the other hand, the perioperative arrhythmia and following cerebral embolism was also attributed to be one factor inducing such neurological hazards.

In the patients with coexistent CAD and CAS (1st group), and also the patients scheduled for CABG or percutaneous coronary intervention (PCI) (2nd group), we, the researchers at Far Eastern Memorial Hospital, attempted to integrate all the parameters mention above, including angiography of coronary and cerebral system, quantitative analysis of nuclear brain scan, biochemical profile, and signals of a new ambulatory device which could record the electrocardiograph (ECG) and electroencephalograph (EEG) simultaneously, in order to define the correlation between them. A chorological relation between EEG signals and ECG signals is our first target to be worked out. Thereafter, we hope to establish a regression model of all involved parameters according to the relation. Such a model, we believe, is essential not only to explain the post-CABG neurological complications, but to prevent them.

Furthermore, for the undetermined ischemic stroke patients who had no obvious culprit artery or embolism source, the paroxysmal arrhythmia had long been regarded as the cause. Whether a paroxysmal atrial fibrillation, which had not been disclosed by routine ECG, could induce most of such a stroke is still not known. With this new ambulatory device which could record the electrocardiograph (ECG) and electroencephalograph (EEG) simultaneously, we want to answer the question.

Condition or disease Intervention/treatment Phase
Stroke Coronary Artery Disease Arrhythmia Procedure: Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph Phase 4

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Diagnostic
Official Title: The Early Diagnosis and Prevention of Ischemic Stroke and Cognition Decline Associated With Coronary Artery Disease Combined With Cerebral Artery Stenosis or Arrhythmia by 24-Hour Simultaneous Recorder of Electrocardiograph and Electroencephalography
Study Start Date : October 2005
Estimated Study Completion Date : August 2007

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Coronary artery stenosis >50% and either carotid or brain artery stenosis > 50%

Exclusion Criteria:

  • Creatinine > 2.0 mg/dL
  • Co-morbidity
  • ER
  • A letter of authorization is not given

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00247533

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Contact: A H Li, MD 886-2-8966-7000 ext 1113

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Far Eastern Memorial Hospital Recruiting
Taipei, Taiwan, 220
Contact: A H Li, MD    886-2-8966-7000 ext 1113   
Principal Investigator: A H Li, MD         
Sponsors and Collaborators
Far Eastern Memorial Hospital
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Principal Investigator: A H Li, MD Far Eastern Memorial Hospital
Layout table for additonal information Identifier: NCT00247533    
Other Study ID Numbers: FEMH-E-940004
First Posted: November 2, 2005    Key Record Dates
Last Update Posted: February 9, 2009
Last Verified: August 2005
Keywords provided by Far Eastern Memorial Hospital:
coronary disease
cerebrovascular disorders
cerebral ischemia
intracranial atherosclerosis
Coronary artery disease
cerebral artery stenosis
percutaneous coronary balloon angioplasty
coronary artery bypass surgery
ischemic stroke
Nuclear brain scan
cognition decline
atrial fibrillation
undetermined ischemic stroke
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Arrhythmias, Cardiac
Constriction, Pathologic
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Heart Diseases
Arterial Occlusive Diseases
Pathological Conditions, Anatomical
Pathologic Processes