Circadian Rhythms and Sleep in Familial DSPS and ASPS
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00246454|
Recruitment Status : Recruiting
First Posted : October 31, 2005
Last Update Posted : September 26, 2016
|Condition or disease|
|Circadian Rhythm Sleep Disorder|
Tremendous progress in the past few years has led to the identification of several circadian clock genes. This now makes it possible to determine how alterations of human circadian clock genes and their expression could lead to differences in circadian and sleep/wake cycle phenotypes. Of particular interest for understanding genetics of the human circadian system are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome (ASPS), because recent studies indicate a genetic basis for these disorders. While it is assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how the circadian clock system, or its interaction with sleep processes, are affected in these individuals.
Participants will complete questionnaires and actigraphy to determine sleep patterns and quality.
|Study Type :||Observational|
|Estimated Enrollment :||156 participants|
|Official Title:||Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)|
|Study Start Date :||September 2003|
|Estimated Primary Completion Date :||September 2017|
|Estimated Study Completion Date :||September 2017|
People with delayed sleep phase syndrome (DSPS).
People with advanced sleep phase syndrome (ASPS).
Control group (people with intermediate sleep patterns).
- Sleep [ Time Frame: 1 night ]Assessment of sleep parameters
- Circadian Timing [ Time Frame: 3 days ]Assessment of circadian activity profiles
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00246454
|Contact: Sabra Abbott, MD, PhDemail@example.com|
|United States, Illinois|
|Chicago, Illinois, United States, 60611|
|Contact: Sabra Abbott 312-503-3561 firstname.lastname@example.org|
|Principal Investigator: Phyllis C. Zee, MD, PhD|
|Principal Investigator:||Phyllis C. Zee, MD, PhD||Northwestern University|