Magnetic Resonance Imaging Study of Geriatric Depression

This study has been completed.
National Alliance for Research on Schizophrenia and Depression
Information provided by (Responsible Party):
Brent Forester, Mclean Hospital Identifier:
First received: October 27, 2005
Last updated: April 6, 2015
Last verified: April 2015
The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.

Condition Intervention
Major Depressive Disorder
Drug: Sertraline

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Nuclear Magnetic Resonance Imaging Study of Treatment With Sertraline in Geriatric Depression

Resource links provided by NLM:

Further study details as provided by Mclean Hospital:

Primary Outcome Measures:
  • HAM-D 17 (Hamilton Depression Rating Scale) [ Time Frame: baseline at study entry week 0 ] [ Designated as safety issue: No ]

    This is a depression severity rating scale measuring symptoms of depression including mood, sleep, appetite, energy, motivation, guilt, suicidal ideation, concentration, physical complaints, paranoia, anxiety, effect on daily functioning and awareness of illness.

    Scale is from 0 (no depression symptoms) up to a maximum of 66 (severe depression symptoms).

  • Geriatric Depression Scale [ Time Frame: baseline at study entry week 0 ] [ Designated as safety issue: No ]
    This is a depression severity rating scale measuring symptoms of depression. Scale is from 0 (no depression symptoms) up to a maximum of 15 (severe depression symptoms).

  • MRS (Magnetic Resonance Spectroscopy) [ Time Frame: at week 13 ] [ Designated as safety issue: No ]

Enrollment: 43
Study Start Date: November 2004
Study Completion Date: August 2008
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Healthy Controls
Healthy Controls undergo MRI and neuropsychological testing
Experimental: Depressed
Depressed subjects receive experimental drug
Drug: Sertraline

Oral Sertraline Dosage started at 25 mg a day, with increases up to maximum dosage strength of 200 mg a day.

Duration of treatment was 12 weeks.

Other Name: Zoloft


Ages Eligible for Study:   55 Years to 89 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • DSM- IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) diagnostic criteria for major depressive disorder
  • Hamilton Depression Scale- 17 item version score of 18 or higher
  • Must speak English
  • Women must be post-menopausal

Exclusion Criteria:

  • A current or pervious psychiatric disorder other than MDD
  • A current unstable medical condition
  • A pacemaker or metal implant
  • History of alcohol or drug dependence or abuse within the past year
  • Current prescription of excluded medications
  • Use of a drug within the last 30 days that was not approved for use by governmental authorities.
  • If you or a family member works at McLean Hospital
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Please refer to this study by its identifier: NCT00245557

United States, Massachusetts
McLean Hospital
Belmont, Massachusetts, United States, 02478
Sponsors and Collaborators
Mclean Hospital
National Alliance for Research on Schizophrenia and Depression
Principal Investigator: Brent Forester, M.D Mclean Hospital
  More Information

Responsible Party: Brent Forester, Director, Mood Disorders Division, Geriatric Psychiatry Research Program, Mclean Hospital Identifier: NCT00245557     History of Changes
Other Study ID Numbers: 2004P-002540 
Study First Received: October 27, 2005
Results First Received: September 16, 2009
Last Updated: April 6, 2015
Health Authority: United States: Food and Drug Administration

Keywords provided by Mclean Hospital:

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mental Disorders
Mood Disorders
Antidepressive Agents
Central Nervous System Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Pharmacologic Actions
Physiological Effects of Drugs
Psychotropic Drugs
Serotonin Agents
Serotonin Uptake Inhibitors
Therapeutic Uses processed this record on May 02, 2016