Cognitive Processing Therapy Versus Its Individual Components in the Treatment of Post-Traumatic Stress Disorder and Depression in Women Who Have Been Sexually Abused
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|ClinicalTrials.gov Identifier: NCT00245232|
Recruitment Status : Completed
First Posted : October 27, 2005
Last Update Posted : March 31, 2015
|Condition or disease||Intervention/treatment||Phase|
|Post-Traumatic Stress Disorder||Behavioral: Cognitive Therapy Behavioral: Cognitive Processing Therapy Behavioral: Written Exposure||Not Applicable|
PTSD is a psychiatric disorder that can occur following exposure to a traumatic event in which grave physical harm occurred or was threatened. PTSD is marked by clear biological changes as well as psychological symptoms. Many people with PTSD repeatedly relive the trauma in the form of flashback episodes, memories, nightmares, or frightening thoughts. This study will evaluate the effectiveness of cognitive processing therapy versus its individual components in treating women with post-traumatic stress disorder and depression brought on by sexual assault.
Participants in this single-blind study will be randomly assigned to receive one of three treatments: cognitive processing therapy (CPT); cognitive therapy (CT); or written exposure (WE). Participants assigned to receive either CPT or CT will attend therapy sessions twice weekly for 6 weeks. CPT will focus on helping each individual to process accurate memories of the traumatic event and to work through any memories that cannot be completely ignored, nor completely integrated back into their thinking. Also included in CPT will be a WE component, in which participants will be encouraged to recall the traumatic event and experience any emotions connected to it. CT will be similar to CPT, but will not include the WE component. Participants assigned to receive only WE will attend one 2-hour session each week. Symptoms of PTSD and depression will be measured at baseline, post-treatment, and at a 6-month follow-up visit.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||228 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Cognitive Processes in PTSD: Treatment|
|Study Start Date :||August 2000|
|Study Completion Date :||April 2005|
- Depression symptoms; measured immediately post-treatment and 6 months post-treatment
- Post-traumatic stress disorder symptoms; measured immediately post-treatment and 6 months post-treatment
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00245232
|United States, Missouri|
|Center for Trauma and Recovery, University of Missouri - St. Louis|
|St. Louis, Missouri, United States, 63121-4499|
|Principal Investigator:||Patricia A. Resick, PhD||National Center for PTSD, Women's Health Sciences Division|