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ClinicalTrials.gov Identifier: NCT00244348
Recruitment Status :
(Investigator has left institution)
Hepatic artery infusion (HAI) with oxaliplatin (OX), systemic 5 fluorouracil (5FU), and leucovorin (HAI/OX/FU) will be implemented using an interventional radiology technique to obviate the need for initial major surgery (catheter placement) in patients who have unresectable liver metastasis from colorectal cancer. The study goal is to reduce tumor size to make possible a complete resection of all lesions. Secondary goals are to reduce or eliminate the complexity usually associated with HAI, to accomplish most or all of the treatment as an outpatient, to reduce costs, and to avoid the hepatotoxicity associated with HAI/floxuridine (FUDR). Oxaliplatin has been selected because of its ease of use, known toxicology, and established efficacy in colorectal cancer.
After entry qualification and registration patients will undergo hepatic artery catheterization via interventional radiology. The catheter will remain in place for two hours while oxaliplatin is infused and then be removed. This treatment will be followed by a 48 hour infusion of 5FU and leucovorin, generally following the principle of FOLFOX 6. These cycles of therapy will be repeated biweekly for six episodes. Hepatic tumor size will be evaluated by CT scan to determine if resectability has been established as the result of tumor size reduction. If so, the patient will be offered resection of the residual lesions in an effort to achieve long term survival.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Age greater than 17 years
Stage IV colorectal cancer
Metastasis limited to the liver considered unresectable for cure by standard methods
Completely resected primary tumor
Life expectancy greater than 3 years excluding cancer
Eastern Cooperative Oncology Group (ECOG) status 0, 1, 2
Absolute granulocyte count greater than 1500
Platelet count greater than 100,000
Adequate hepatic function
Adequate renal function
Concomitant anticancer therapy other than this protocol
Pregnancy or lactation
Last treatment for colon cancer less than 4 weeks from this protocol