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Trial record 71 of 752 for:    Anti-Infective Agents AND Antibiotics, Antitubercular AND culture

Optimizing Antibiotic Use in Long Term Care

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00243360
Recruitment Status : Completed
First Posted : October 24, 2005
Last Update Posted : October 24, 2005
Information provided by:
Agency for Healthcare Research and Quality (AHRQ)

Brief Summary:
The purpose of this study was to determine if a multi-faceted intervention to implement diagnostic and therapeutic algorithms for management of suspected urinary infection in nursing home residents could reduce antibiotic prescribing for urinary indications in this population.

Condition or disease Intervention/treatment Phase
Urinary Tract Infection, Antibiotic Use Behavioral: diagnostic and treatment clinical algorithms Not Applicable

Detailed Description:
Antibiotic use is intense in nursing homes and frequently inappropriate when prescribed for urinary indications. Evidence from randomized controlled trials suggests that treatment of asymptomatic bacteriuria, the presence of bacteria in the urine in the absence of urinary symptoms, is not beneficial. Despite this, one in three prescriptions for urinary indications are for asymptomatic bacteriuria. To improve antibiotic prescribing in this setting we conducted a cluster randomized trial of a strategy to implement diagnostic and treatment algorithms for urinary infection. 24 nursing homes were randomized to either the intervention (implemented at the nursing home level using a multi-faceted approach: small group interactive sessions for nurses, one-on-one interviews for physicians, videotapes, written material, and outreach visits) or to usual care.

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Educational/Counseling/Training
Official Title: Optimizing Antibiotic Use in Long Term Care
Study Start Date : January 2001
Study Completion Date : July 2003

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Antimicrobial prescriptions

Secondary Outcome Measures :
  1. Urinary cultures,
  2. hospitalizations, deaths

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Individuals- all residents eligible
  2. Nursing homes

    • Free standing long term care facilities with >100 beds
    • No stated policy for diagnosis or treatment of urinary tract infections
    • The facility agrees to refrain from introducing new strategies for antibiotic utilization or clinical pathways during study

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00243360

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Canada, Ontario
McMaster University
Hamilton, Ontario, Canada, L8N 3Z5
Sponsors and Collaborators
Agency for Healthcare Research and Quality (AHRQ)
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Principal Investigator: Mark B Loeb, MD MSc FRCPC McMaster University

Layout table for additonal information Identifier: NCT00243360     History of Changes
Other Study ID Numbers: U18HS011113-01 ( U.S. AHRQ Grant/Contract )
First Posted: October 24, 2005    Key Record Dates
Last Update Posted: October 24, 2005
Last Verified: October 2005
Keywords provided by Agency for Healthcare Research and Quality (AHRQ):
Urinary tract infections,
antibiotic use,
long term care facilities
Additional relevant MeSH terms:
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Urinary Tract Infections
Urologic Diseases
Anti-Bacterial Agents
Antibiotics, Antitubercular
Anti-Infective Agents
Antitubercular Agents