The Effect of Fatty Acid Composition on Energy Intake and Satiety
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|ClinicalTrials.gov Identifier: NCT00242021|
Recruitment Status : Completed
First Posted : October 19, 2005
Last Update Posted : October 14, 2009
The objective of the study is to investigate the effect of fatty acid composition of a fat supplement:
- acutely (after single intake) on subjective and objective measurements of hunger, satiety and wellness, on energy intake, and postprandial hormonal changes;
- in the long-term (after one week) on (regulators of) fat tissue metabolism.
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Behavioral: Fatty acid composition of a margarine (spread)||Not Applicable|
One of the physiological factors regulating the food intake pattern is satiety. Satiety is defined as the absence of ingestive motivation, which ends when the next meal is initiated (Blundell et al., 1996). Food intake affects a number of physiological objective parameters in blood known to be involved in signaling satiety, such as glucose (Melanson et al, 1999; Chapman et al, 1999; Campfield et al, 1996), insulin (Speechly et al, 2000) and cholecystokinin (CCK) (Gutzwiller et al., 2000; Beglinger et al., 2001; French et al., 2000; Degen et al., 2001; Burton-Freemanet al., 2002, 2004). More recently, the gastric hormone ghrelin was identified as a marker for hunger and meal initiation (De Graaf et al, 2004). Ghrelin concentrations in blood were highly correlated with subjective measures of appetite. PYY, a gut hormone produced postprandially, will be measured in this study because it has been mentioned that this hormone inhibits food intake (Batterham et al., 2003). The baseline level of PYY is lower in obese subjects than in lean subjects. The two groups different in body weight will therefore show different baseline levels, and perhaps different curves as well.
Humans do not only eat in response to a metabolic or physiological need. Humans also respond to a significant extend to other internal subjective and emotional signals (cues). The exact relations between the physiological internal signals and subjective and emotional internal signals are not known. Besides also external and social factors modulate physiological-derived hunger and satiety signals.
In the present clinical trial, the effect of fatty acid composition of a fat supplement will be studied on hunger and satiety. In the supplement a mixture of fatty acids known for their satiating effect will be tested and will be compared with a control supplement containing fatty acids normally consumed with breakfast.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Fatty Acid Composition of a Fat Supplement on Energy Intake, Satiety and Fat Metabolism in Lean and Obese Men|
|Study Start Date :||October 2005|
|Actual Primary Completion Date :||December 2005|
|Actual Study Completion Date :||December 2005|
- Subjective and objective measurements of hunger, satiety and wellness, on energy intake, and postprandial hormonal changes
- After one week supplementation the effect on (regulators of) fat tissue metabolism will be examined.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00242021
|TNO Quality of Life|
|Zeist, Utrecht, Netherlands, 3704 HE|
|Principal Investigator:||Wilrike Pasman, PhD||TNO|